Evidence map›Paper›PMID 41889916›Full record

ArticlebioRxiv : the preprint server for biology2026

Loss of

Emma Carley, Sandra Sandria, Xueyan Peng, Kerri Davidson, Aya Nassereddine, Changwan Ryu, Rachel Rivera, John McGovern, Alexander Ghincea, C Patrick Lusk and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Emma CarleyDepartment of Cell Biology, Yale School of Medicine.ORCID 0000-0001-6527-756X
Sandra SandriaDepartment of Cell Biology, Yale School of Medicine.ORCID 0000-0003-1491-106X
Xueyan PengSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine.
Kerri DavidsonDepartment of Cell Biology, Yale School of Medicine.ORCID 0000-0001-9432-6359
Aya NassereddineDepartment of Molecular, Cell and Developmental Biology, Yale University.ORCID 0009-0008-3314-9174
Changwan RyuSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine.ORCID 0000-0001-6211-4327
Rachel RiveraDepartment of Cell Biology, Yale School of Medicine.ORCID 0009-0006-9739-2339
John McGovernSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine.
Alexander GhinceaSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine.ORCID 0000-0001-7404-9921
C Patrick LuskDepartment of Cell Biology, Yale School of Medicine.ORCID 0000-0003-4703-0533
Erica L HerzogSection of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, Yale School of Medicine.ORCID 0000-0002-7508-8575
Valerie HorsleyDepartment of Molecular, Cell and Developmental Biology, Yale University.ORCID 0000-0002-1254-5839
Megan C KingDepartment of Cell Biology, Yale School of Medicine.ORCID 0000-0002-1688-2226

Funding

Noradrenergic mechanisms of IPFR01HL163984 · NHLBI · YALE UNIVERSITY · PI Erica L Herzog · 2022 to 2026
$3.7M
Mechanism and Impact of Dermal adipocyte remodeling in skin fibrosisR01AR076938 · NIAMS · YALE UNIVERSITY · PI ATIT, RADHIKA P, HORSLEY, VALERIE · 2020 to 2024
$2.4M
Predoctoral Program in Cellular, Molecular and Quantitative Biology (CMQBTP)T32GM145469 · NIGMS · YALE UNIVERSITY · PI Susan J Baserga, Charles Patrick Lusk · 2023 to 2026
$2.2M
Mitochondrial DNA and Sex Differences in Scleroderma-Associated ILDR01HL178097 · NHLBI · YALE UNIVERSITY · PI FEGHALI-BOSTWICK, CAROL A., HERZOG, ERICA L · 2025 to 2025
$1.5M
The genetic and non-genetic responses of chromatin to forceR35GM153474 · NIGMS · YALE UNIVERSITY · PI MEGAN C KING · 2024 to 2026
$1.3M
High Performance Computing Instrumentation for the Yale Center for Genome AnalysisS10OD030363 · OD · YALE UNIVERSITY · PI MANE, SHRIKANT M · 2022 to 2022
$1.2M
Metabolic regulation of inflammation during tissue repairR01AR084558 · NIAMS · YALE UNIVERSITY · PI Valerie Horsley, KATHRYN MILLER-JENSEN · 2025 to 2026
$956k
Defining the role of the nuclear lamina in the mechanical regulation of lung fibrosisF31HL158119 · NHLBI · YALE UNIVERSITY · PI CARLEY, EMMA · 2022 to 2023
$57k
Defining a mechanism for inner nuclear membrane protein SUN2's mechanical regulation of skin fibrosisF31AR085488 · NIAMS · YALE UNIVERSITY · PI SANDRIA, SANDRA DEL CARMEN · 2025 to 2025
$50k
NHLBI NIH HHS F31 HL158119NHLBI NIH HHS R01 HL163984NHLBI NIH HHS R01 HL178097NIAMS NIH HHS F31 AR085488NIAMS NIH HHS R01 AR076938NIAMS NIH HHS R01 AR084558NIGMS NIH HHS R35 GM153474NIGMS NIH HHS T32 GM145469NIH HHS S10 OD030363
6 · The paper itself

Abstract

Fibrosis and pathological stiffening of tissue are driven by mechanical and biochemical signaling pathways. Here, we find that Sun2, an integral inner nuclear membrane component of Linker of Nucleoskeleton and Cytoskeleton (LINC) complexes, is up-regulated in the lung of patients suffering from fibrotic conditions and in fibroblasts during an injury-induced mouse model of lung fibrosis. Sun2 protein levels also increase in primary lung fibroblasts in a substrate stiffness-dependent manner.

Identifiers

PMID41889916
PMCPMC13015507

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.