ArticlebioRxiv : the preprint server for biology2026
An epigenetic mechanism of azole tolerance facilitates acquired antifungal resistance in
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Antibiotic tolerance paves the way for acquired resistance in bacterial pathogens. However, the mechanisms of tolerance and its evolutionary role in acquired resistance in pathogenic fungi, particularly molds, remains elusive. Here, we identified an In hibitor of G rowth domain protein (IngB) as a novel epigenetic regulator of azole tolerance in Importance: While antimicrobial drug resistance causes a significant adverse effect on human health, drug tolerance can also lead to insufficient pathogen clearance, resulting in infection relapse. However, the mechanisms of antifungal drug tolerance and its evolutionary role in acquired drug resistance in pathogenic fungi, particularly the molds, remains elusive. We identified IngB as a novel regulator of azole tolerance in
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