In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Amanda R VicentinoDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus CO.
Anis Karimpour-FardDepartment of Medicine, Division of General Internal Medicine, University of Colorado School of Medicine CO.ORCID 0000-0003-4249-4363 Brian L StaufferDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus CO.ORCID 0000-0003-3418-7750 Shelley D MiyamotoDepartment of Pediatrics, Division of Cardiology, University of Colorado Anschutz Medical Campus CO.ORCID 0000-0002-8029-981X Steven LipshultzDepartment of Pediatrics, University at Buffalo Jacobs School of Medicine and Biomedical Sciences NY.
Carmen C SucharovDepartment of Medicine, Division of Cardiology, University of Colorado Anschutz Medical Campus CO.
Pediatric Cardiomyopathy Registry Investigators
Funding
PHACS - Data and Operations CenterU01HD052102 · NICHD · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI WILLIAMS, PAIGE L · 2005 to 2019
$242.7MZebrafish Screens for Genetic Modifiers and Human Application in T-ALLP01CA068484 · NCI · DANA-FARBER CANCER INSTITUTE · PI KUTOK, JEFFERY LORNE · 1995 to 2010
$31.9MPediatric HIV/AIDS Cohort Study (PHACS): Understanding Maternal HIV Disease through Pregnancy and the Postpartum Period and its Role in Child Health OutcomesU01HD052104 · NICHD · TULANE UNIVERSITY OF LOUISIANA · PI VAN DYKE, RUSSELL B. · 2005 to 2019
$15.7MPEDIATRIC CARDIOMYOPATHY REGISTRYR01HL053392 · NHLBI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 1995 to 2009
$8.3MCardiovascular Status of HAART-Exposed Infants/ChildrenR01HL072705 · NHLBI · UNIVERSITY OF ROCHESTER · PI LIPSHULTZ, STEVEN EDWARD · 2002 to 2006
$5.6MSpecification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3MTRAINING PROGRAMS IN CARDIOVASCULAR PHARMACOLOGYT32HL007188 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SZCZESNA-CORDARY, DANUTA · 1985 to 2011
$3.8MWomen and Infants Transmission Study IVU01AI050274 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI RICH, KENNETH C · 2001 to 2005
$3.6MPrognostic Significance of microRNA Expression in Children with CardiomyopathyR01HL139968 · NHLBI · WAYNE STATE UNIVERSITY · PI LIPSHULTZ, STEVEN EDWARD, MIYAMOTO, SHELLEY DEANNE · 2018 to 2021
$3.3MPediatric Cardiomyopathy Specimen RepositoryR01HL087000 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI TOWBIN, JEFFREY ALLEN · 2007 to 2010
$2.2MHAART Associated Cardiotoxicity in HIV-Infected ChildrenR01HL078522 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LIPSHULTZ, STEVEN EDWARD · 2004 to 2008
$2.0MAtherosclerotic Risk and Response to Exercise Intervention in HIV+ ChildrenR01HL095127 · NHLBI · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MILLER, TRACIE L · 2008 to 2010
$1.1MNCI NIH HHS P01 CA068484NCI NIH HHS R01 CA127642NHLBI NIH HHS F31 HL094100NHLBI NIH HHS K24 HL150630NHLBI NIH HHS K30 HL004537NHLBI NIH HHS R01 HL053392NHLBI NIH HHS R01 HL072705NHLBI NIH HHS R01 HL078522NHLBI NIH HHS R01 HL087000NHLBI NIH HHS R01 HL095127NHLBI NIH HHS R01 HL139968NHLBI NIH HHS R13 HL087708NHLBI NIH HHS R35 HL161185NHLBI NIH HHS T32 HL007188NIAID NIH HHS U01 AI050274NICHD NIH HHS U01 HD052102NICHD NIH HHS U01 HD052104
6 · The paper itselfAbstract
Background: Pediatric dilated cardiomyopathy (DCM) is a rare, progressive heart disease with variable outcomes that range from recovery to heart transplantation. To date, there are no prognostic biomarkers for children with DCM. Identifying circulating biomarkers that are associated with clinical outcomes is critical for personalized management. Methods: miRNAs were identified by RNA-seq, whereas proteins were identified by SomaScan Results: Thirty patients experienced poor outcomes (cardiac transplantation, mechanical circulatory support, or death) and 19 patients recovered left ventricular function. Distinct miRNA and protein signatures differentiated outcomes groups. Top candidate proteins (COL2A1, CXCL12, and ADGRF5) and miRNAs (miR-874-3p, miR-335-3p, miR-323a-3p) demonstrated strong discriminatory performance within the study cohort (recovered vs poor outcomes; Area Under the Curve of 0.92). Ingenuity Pathway Analysis implicates cardiac remodeling, fibrosis, and inflammatory signaling as central pathways differentiating patient outcomes. Conclusions: Circulating miRNA and protein signatures at presentation identify a circulating molecular signature associated with divergent clinical trajectories in pediatric DCM. These findings support the potential utility of multi-omic biomarkers for early risk stratification and provide insight into mechanisms underlying divergent outcomes.
Indexed as
biomarkersmachine learningpediatric dilated cardiomyopathysecreted factors
Identifiers
PMID41889895
PMCPMC13015289
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