Evidence map›Paper›PMID 41889870›Full record

ArticlebioRxiv : the preprint server for biology2026

Midbrain

Tim Gruber, Robert A Chesters, Luca Fagnocchi, Xinyang Yu, Zhen Fu, Kristin Gallik, Heiko Backes, Robert Vaughan, Melanie Huber, Meri De Angelis and 11 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Tim GruberDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0001-6884-7046
Robert A ChestersNeurocircuit Development and Function, German Institute for Nutrition (DIfE), Potsdam-Rehbrücke, Germany.ORCID 0000-0003-1850-4728
Luca FagnocchiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-9551-5474
Xinyang YuSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0001-8026-4839
Zhen FuBioinformatics and Biostatistics Core Facility, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-8120-590X
Kristin GallikOptical Imaging Core Facility, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0003-3587-1028
Heiko BackesMax Planck Institute for Metabolism Research, Cologne, Germany.ORCID 0000-0002-0318-1615
Robert VaughanDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-3046-4207
Melanie HuberGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Meri De AngelisGerman Center for Diabetes Research (DZD), Neuherberg, Germany.
Josef GullmetsDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0003-2466-7574
Holly DykstraDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Stefanos ApostleDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0001-7257-7421
Taylor CookDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.
Justin KulchyckiDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-4000-9320
Lisa DeCampDepartment of Metabolism and Nutritional Programming, Van Andel Institute, Grand Rapids, MI, USA.
Timo D MüllerGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0002-0624-9339
Katharina TimperGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0002-4988-6338
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID 0000-0002-9120-7060
Rachel N LippertGerman Center for Diabetes Research (DZD), Neuherberg, Germany.ORCID 0000-0002-6905-2234
J Andrew PospisilikDepartment of Epigenetics, Van Andel Institute, Grand Rapids, MI, USA.ORCID 0000-0002-9745-0977

Funding

Master regulators of unexplained variation in disease riskR01HG012444 · NHGRI · VAN ANDEL RESEARCH INSTITUTE · PI NADEAU, JOSEPH H., POSPISILIK, JOHN ANDREW · 2021 to 2025
$9.6M
A Trim28-ERV axis drives phenotypic variation in obesityR01DK132216 · NIDDK · VAN ANDEL RESEARCH INSTITUTE · PI POSPISILIK, JOHN ANDREW, SCHONES, DUSTIN EDWARD · 2023 to 2025
$1.8M
NHGRI NIH HHS R01 HG012444NIDDK NIH HHS R01 DK132216
6 · The paper itself

Abstract

Binge-eating disorder (BED) is the most common eating disorder worldwide and carries life-altering comorbidities. While genetic and environmental risk factors have been identified, the mechanisms that determine inter-individual susceptibility to BED remain largely unknown. Here, we demonstrate that developmental dosage of the DNA hydroxymethylase

Identifiers

PMID41889870
PMCPMC13015413

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.