Evidence map›Paper›PMID 41889864›Full record

ArticlebioRxiv : the preprint server for biology2026

High-Fidelity Long-term Whole-embryo Lineage and Fate Reconstruction by Iterative Tracking with Error Correction.

Mengfan Wang, Qinghua Zhang, Congchao Wang, Yunfeng Chi, Wei Zheng, Zeyu Mu, Xiangyu Cao, Weizhan Zhang, Boao Yang, Alexander F Schier and 3 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mengfan WangBradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University; Arlington, VA 22203, USA.
Qinghua ZhangDepartment of Automation, Tsinghua University; Beijing, 100084, China.ORCID 0009-0007-7471-9690
Congchao WangBradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University; Arlington, VA 22203, USA.
Yunfeng ChiDepartment of Automation, Tsinghua University; Beijing, 100084, China.
Wei ZhengBradley Department of Electrical and Computer Engineering, Virginia Polytechnic Institute and State University; Arlington, VA 22203, USA.
Zeyu MuDepartment of Automation, Tsinghua University; Beijing, 100084, China.
Xiangyu CaoDepartment of Automation, Tsinghua University; Beijing, 100084, China.
Weizhan ZhangDepartment of Automation, Tsinghua University; Beijing, 100084, China.
Boao YangDepartment of Automation, Tsinghua University; Beijing, 100084, China.
Alexander F SchierBiozentrum, University of Basel; Basel, 4056, Switzerland.ORCID 0000-0001-7645-5325
Joaquin Navajas AcedoBiozentrum, University of Basel; Basel, 4056, Switzerland.ORCID 0000-0003-2855-6660
Yinan WanBiozentrum, University of Basel; Basel, 4056, Switzerland.ORCID 0000-0002-7076-1791
Guoqiang YuDepartment of Automation, Tsinghua University; Beijing, 100084, China.ORCID 0000-0002-6743-7413

Funding

Novel Genetically Encoded Indicators for Interrogating Neuron-Astrocyte Communication Across TimescalesU19NS123719 · NINDS · SALK INSTITUTE FOR BIOLOGICAL STUDIES · PI NIMMERJAHN, AXEL · 2021 to 2025
$10.7M
Decoding Astrocyte Signaling in Neural Circuitry with Novel Computational Modeling and Analytical ToolsR01MH110504 · NIMH · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YUE WANG · 2017 to 2026
$6.1M
NIMH NIH HHS R01 MH110504NINDS NIH HHS U19 NS123719
6 · The paper itself

Abstract

Reconstructing the complete cell lineages and fate maps of a living embryo has remained a central challenge in developmental biology. Here we introduce ITEC (Iterative Tracking with Error Correction), a fully unsupervised method that automatically reconstructs the lineage of every cell in the embryo with high fidelity. ITEC was validated with manually annotated lineages on four cross-species datasets including zebrafish, mouse, and

Indexed as

cell trackingembryonic development analysisfate mappinglineage reconstruction

Identifiers

PMID41889864
PMCPMC13015363

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.