Evidence map›Paper›PMID 41889855›Full record

ArticlebioRxiv : the preprint server for biology2026

ULK1 drives NDP52-mediated selective autophagic degradation of MHC-I to promote immune evasion in HPV-positive head and neck cancer.

Lexi Vu, Nicholas S Giacobbi, Mohamed I Khalil, Canchai Yang, William J Eckerman, Evelyn Gomez Recinos, Johnathon D Garber, Hyomin Son, Prerna Chahal, Dara M Villa and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Lexi VuDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Nicholas S GiacobbiDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Mohamed I KhalilDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Canchai YangDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
William J EckermanDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Evelyn Gomez RecinosDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Johnathon D GarberDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Hyomin SonDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Prerna ChahalDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Dara M VillaDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Tasha SrivastavaDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Abigail Z BennettDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Katie R MartinDepartment of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.
Craig C WelbonCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota, USA.
Caitlin WilliamsonCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota, USA.
William C SpanosCancer Biology and Immunotherapies Group, Sanford Research, Sioux Falls, South Dakota, USA.
Jeffrey P MacKeiganDepartment of Pediatrics and Human Development, College of Human Medicine, Michigan State University, Grand Rapids, MI, USA.
Andrew J OliveDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.
Dohun PyeonDepartment of Microbiology, Genetics, and Immunology, Michigan State University, East Lansing, MI, USA.ORCID 0000-0003-1970-844X

Funding

Chemokine-mediated antigen-specific T cell responses and immunotherapies to treat head and neck cancerR01DE029524 · NIDCR · MICHIGAN STATE UNIVERSITY · PI PYEON, DOHUN, SPANOS, WILLIAM CHARLES · 2020 to 2024
$3.2M
Regulators of IFN-gamma responses during Mycobacterium tuberculosis infectionR01AI165618 · NIAID · MICHIGAN STATE UNIVERSITY · PI Andrew Olive · 2022 to 2026
$2.6M
ULK Inhibition Rewires Tumor and Immune Cell MetabolismR01CA297993 · NCI · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI Russell Graham Jones, Jeffrey Paul MacKeigan · 2025 to 2026
$1.4M
Immune receptor degradation for immune evasion of head and neck cancerR01DE033797 · NIDCR · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI QING-SHENG MI, Dohun Pyeon · 2025 to 2026
$1.3M
Membrane Ubiquitin Ligase-Driven Immune Evasion in HPV+ Head and Neck CancerF31DE034281 · NIDCR · HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES · PI VU, LEXI · 2024 to 2025
$95k
NCI NIH HHS R01 CA297993NIAID NIH HHS R01 AI165618NIDCR NIH HHS F31 DE034281NIDCR NIH HHS R01 DE029524NIDCR NIH HHS R01 DE033797
6 · The paper itself

Abstract

Antigen presentation by major histocompatibility complex class I (MHC-I) is critical for tumor cell killing by CD8

Identifiers

PMID41889855
PMCPMC13015544

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.