ArticlebioRxiv : the preprint server for biology2026
Preferential formation of NUP98-KDM5A condensates at specific H3K4me3-rich loci drives leukemogenic gene expression.
Augusto Berrocal, Jonathan E Sandoval, Neha Khetan, Alexa Ma, Tianhong Wang, Camille Moore, Geeta J Narlikar, Hao Li, Danica Galonić Fujimori, Bo Huang
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
10 authors.
Augusto BerrocalDepartment of Pharmaceutical Chemistry, University of California at San Francisco, United States.
Jonathan E SandovalDepartment of Cellular and Molecular Pharmacology, University of California at San Francisco, United States.
Neha KhetanDepartment of Biochemistry and Biophysics, University of California at San Francisco, United States.
Alexa MaDepartment of Molecular and Cellular Biology, University of California, Berkeley, Berkeley, United States.
Tianhong WangDepartment of Pharmaceutical Chemistry, University of California at San Francisco, United States.
Camille MooreDepartment of Biochemistry and Biophysics, University of California at San Francisco, United States.
Geeta J NarlikarDepartment of Biochemistry and Biophysics, University of California at San Francisco, United States.
Hao LiDepartment of Biochemistry and Biophysics, University of California at San Francisco, United States.
Danica Galonić FujimoriDepartment of Pharmaceutical Chemistry, University of California at San Francisco, United States.ORCID 0000-0002-4066-9417 Bo HuangDepartment of Pharmaceutical Chemistry, University of California at San Francisco, United States.ORCID 0000-0003-1704-4141 Funding
UCSF IRACDA Scholars ProgramK12GM081266 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Raymond M. Esquerra, HOLLY A. INGRAHAM · 2007 to 2026
$19.4MModulation and functional characterization of protein condensation in chromatin organizationU01DK127421 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HUANG, BO, NARLIKAR, GEETA J · 2020 to 2024
$5.4MCellular and Tissue Rejuvenation through Transcriptional ReprogrammingR01AG083524 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HAO LI, SAUL A VILLEDA · 2023 to 2026
$2.5MIdentifying molecular traits associated with extreme human longevity using an AI based integrative approachR33AG078793 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI EVANS, DANIEL SPENCER, LI, HAO · 2025 to 2025
$1.4MWide field-of-view Spinning Disk Confocal with Photoactivation and PhotobleachingS10OD017993 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI THORN, KURT · 2015 to 2015
$274kNIA NIH HHS R01 AG083524NIA NIH HHS R33 AG078793NIDDK NIH HHS U01 DK127421NIGMS NIH HHS K12 GM081266NIH HHS S10 OD017993
6 · The paper itselfAbstract
Chromosomal translocations involving NUP98 generate fusion proteins that alter gene expression programs, yet the fundamental principles governing their gene targeting and condensate behavior remain poorly understood. Using NUP98-KDM5A as a model, we integrate cellular imaging,
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PMID41889846
PMCPMC13015470
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