Evidence map›Paper›PMID 41889831›Full record

ArticlebioRxiv : the preprint server for biology2026

Dominant α-tubulin mutations rescue tauopathy neurodegenerative phenotypes in

Sarah J Benbow, Aleen D Saxton, Misa Baum, Rikki L Uhrich, Jade G Stair, Kelly Keene, Chloe Dahleen, Linda Wordeman, Nicole F Liachko, Rebecca L Kow and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Sarah J BenbowGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.ORCID 0000-0001-9820-2564
Aleen D SaxtonGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.
Misa BaumGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.
Rikki L UhrichGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.
Jade G StairGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.
Kelly KeeneGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.
Chloe DahleenGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.
Linda WordemanDepartment of Neurobiology and Biophysics, University of Washington, 1705 NE Pacific Street, Box 357290, Seattle, WA 98195 Seattle, Washington 98195, USA.
Nicole F LiachkoGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.
Rebecca L KowGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.
Brian C KraemerGeriatrics Research Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, Seattle, WA 98108, USA.ORCID 0000-0002-2252-7634

Funding

Neurobehavior, Neuropathology, and Risk Factors in Alzheimer's DiseaseT32AG052354 · NIA · UNIVERSITY OF WASHINGTON · PI Brian C. Kraemer, ELAINE R. PESKIND · 2016 to 2026
$6.7M
Developing Neuroprotective Strategies for Tau and TDP-43 Proteinopathy in FTLDR01NS064131 · NINDS · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI KRAEMER, BRIAN C. · 2009 to 2022
$5.0M
TDP-43 in Alzheimer's diseaseR01AG066729 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI LIACHKO, NICOLE FARON · 2021 to 2025
$2.6M
Formation of Tau RNA Complexes disrupts tau function and drives tau neuropathologyR01AG084680 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI KRAEMER, BRIAN C. · 2023 to 2025
$1.9M
Investigating how SUT-6/NIPP1 regulates pathological tauR01AG084552 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI Rebecca Liang Kow · 2024 to 2026
$1.7M
Mutant Tubulins Confer Resistance to Pathological TauR00AG073455 · NIA · SEATTLE INST FOR BIOMEDICAL/CLINICAL RES · PI Sarah Jean Zimmerman Benbow · 2024 to 2026
$742k
Mutant tubulins confer resistance to pathological tauK99AG073455 · NIA · UNIVERSITY OF WASHINGTON · PI BENBOW, SARAH JEAN ZIMMERMAN · 2021 to 2022
$255k
BLRD VA I01 BX005762BLRD VA IK6 BX006467NIA NIH HHS K99 AG073455NIA NIH HHS R00 AG073455NIA NIH HHS R01 AG066729NIA NIH HHS R01 AG084552NIA NIH HHS R01 AG084680NIA NIH HHS T32 AG052354NINDS NIH HHS R01 NS064131
6 · The paper itself

Abstract

Tau protein, the primary component in neurofibrillary tangles characteristic of Alzheimer's Disease and related dementia disorders, normally regulates microtubule growth and stability. While tau dysfunction contributes to the progression of tauopathies, the role of microtubules in disease has remained unclear. Through forward genetic screening in

Indexed as

Alzheimer’s diseasemicrotubuleneurodegenerationtautauopathytubulin

Identifiers

PMID41889831
PMCPMC13015788

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.