Evidence map›Paper›PMID 41889829›Full record

ArticlebioRxiv : the preprint server for biology2026

IR-AMES uncovers structure and composition of Alzheimer's tau oligomers.

Qing Xia, Qingbo Wang, Danchen Jia, Dashan Dong, Mingsheng Li, Eliana Sherman, Jianpeng Ao, Qian Ren, Huan Bao, Lulu Jiang and 1 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Qing XiaDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, United States.ORCID 0000-0002-5939-2972
Qingbo WangDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Danchen JiaDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, United States.
Dashan DongDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, United States.
Mingsheng LiDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, United States.
Eliana ShermanDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Jianpeng AoDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, United States.
Qian RenDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.
Huan BaoDepartment of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22903, United States.
Lulu JiangDepartment of Neuroscience, University of Virginia School of Medicine, Charlottesville, Virginia 22908, United States.
Ji-Xin ChengDepartment of Electrical and Computer Engineering, Boston University, Boston, Massachusetts 02215, United States.

Funding

Vibrational Spectroscopic Imaging to Unveil Hidden Signatures in Living SystemsR35GM136223 · NIGMS · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2020 to 2025
$5.7M
Rapid AST through Metabolic Imaging at Single Cell LevelR01AI141439 · NIAID · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI Ji-Xin Cheng · 2019 to 2026
$4.7M
Epitranscriptomic Mechanism in pathogenesis of Alzheimer’s diseaseR01AG091577 · NIA · UNIVERSITY OF VIRGINIA · PI Lulu Jiang · 2025 to 2026
$1.5M
Mapping Cancer Metabolism by Mid-infrared Photothermal MicroscopyR33CA261726 · NCI · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI CHENG, JI-XIN · 2021 to 2023
$1.2M
Designer nanodiscs to probe and reprogram membrane biologyR35GM156801 · NIGMS · UNIVERSITY OF VIRGINIA · PI Huan Bao · 2025 to 2026
$801k
NCI NIH HHS R33 CA261726NIAID NIH HHS R01 AI141439NIA NIH HHS R01 AG091577NIGMS NIH HHS R35 GM136223NIGMS NIH HHS R35 GM156801
6 · The paper itself

Abstract

Tau misfolding and aggregation are central to cognitive decline in Alzheimer's disease and related neurodegenerative disorders

Identifiers

PMID41889829
PMCPMC13015324

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.