Evidence map›Paper›PMID 41889812›Full record

ArticlebioRxiv : the preprint server for biology2026

An Advanced Mobile Laboratory to enable field-based microbial ecology and cell biology across scales.

N Leisch, S Baars, T Beavis, P Bertucci, C Bhickta, M Bonadonna, C M Brannon, L Burgués-Palau, P Cherek, F Chevalier and 42 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

52 authors.

N LeischMobile Laboratories Services, European Molecular Biology Laboratory Heidelberg, Germany.ORCID 0000-0001-7375-3749
S BaarsBiozentrum, University of Basel. Switzerland.
T BeavisDevelopmental Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
P BertucciDevelopmental Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
C BhicktaCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
M BonadonnaMobile Laboratories Services, European Molecular Biology Laboratory Heidelberg, Germany.
C M BrannonDepartment of Biology, Stanford University, USA.
L Burgués-PalauCell and Plant Physiology Laboratory, CNRS, CEA, INRAE, IRIG, Université Grenoble Alpes, Grenoble, France.
P CherekMobile Laboratories Services, European Molecular Biology Laboratory Heidelberg, Germany.
F ChevalierCell and Plant Physiology Laboratory, CNRS, CEA, INRAE, IRIG, Université Grenoble Alpes, Grenoble, France.
J DecelleCell and Plant Physiology Laboratory, CNRS, CEA, INRAE, IRIG, Université Grenoble Alpes, Grenoble, France.
M DemulderBiozentrum, University of Basel. Switzerland.
G DeyCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
O DudinDepartment of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
E DukeBiological X-ray Imaging, European Molecular Biology Laboratory Hamburg, Germany.
B D EngelBiozentrum, University of Basel. Switzerland.
E FlaumCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
S FloriDevelopmental Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
B GalletUniversité Grenoble Alpes, CEA, CNRS, IBS, Grenoble, France.
P GuichardDepartment of Molecular and Cellular Biology, Faculty of Sciences, University of Geneva, Switzerland.
A HalavatyiAdvanced Light Microscopy Facility, European Molecular Biology Laboratory Heidelberg, Germany.
V HamelDepartment of Molecular and Cellular Biology, Faculty of Sciences, University of Geneva, Switzerland.
M JacobovitzCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
C JueryCell and Plant Physiology Laboratory, CNRS, CEA, INRAE, IRIG, Université Grenoble Alpes, Grenoble, France.
M LaporteUniversité Claude Bernard Lyon 1, MeLiS, CNRS UMR95284, INSERM U1314, Lyon, France.
S MatteiMolecular Systems Biology. European Molecular Biology Laboratory Heidelberg, Germany.
F MikusCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
K MocaerCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
K MoogDevelopmental Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
M OlivettaDepartment of Biochemistry, Faculty of Sciences, University of Geneva, Geneva, Switzerland.
M PavieCell and Plant Physiology Laboratory, CNRS, CEA, INRAE, IRIG, Université Grenoble Alpes, Grenoble, France.
R PepperkokCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
A Perez-BoeremaBiozentrum, University of Basel. Switzerland.
L PlanatDevelopmental Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
M PrakashBioengineering, Stanford University, USA.
E W PyleMolecular Systems Biology. European Molecular Biology Laboratory Heidelberg, Germany.
C R RhodesCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
I Romero-BreyCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
P RonchiElectron Microscopy Core Facility, European Molecular Biology Laboratory Heidelberg, Germany.
H RosaMolecular Systems Biology. European Molecular Biology Laboratory Heidelberg, Germany.
A Rubio RamosDepartment of Molecular and Cellular Biology, Faculty of Sciences, University of Geneva, Switzerland.
C Saint-DonatCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
Y SchwabCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
H ShahCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
A M SteyerMolecular Systems Biology. European Molecular Biology Laboratory Heidelberg, Germany.
A SvetloveBiological X-ray Imaging, European Molecular Biology Laboratory Hamburg, Germany.
G ToullecCell and Plant Physiology Laboratory, CNRS, CEA, INRAE, IRIG, Université Grenoble Alpes, Grenoble, France.
F VincentDevelopmental Biology, European Molecular Biology Laboratory, Heidelberg, Germany.
T WiegandMobile Laboratories Services, European Molecular Biology Laboratory Heidelberg, Germany.
W WietrzynskiBiozentrum, University of Basel. Switzerland.
D YeeCell Biology and Biophysics, European Molecular Biology Laboratory Heidelberg, Germany.
S ZwahlenDevelopmental Biology, European Molecular Biology Laboratory, Heidelberg, Germany.

Funding

Molecular Biophysics Training Program at StanfordT32GM008294 · NIGMS · STANFORD UNIVERSITY · PI HUANG, KERWYN C. · 1989 to 2019
$7.4M
NIGMS NIH HHS T32 GM008294
6 · The paper itself

Abstract

Microbial biodiversity is central to ecosystem function, yet mechanistic insights into the cell biology of environmental organisms remain limited. The underlying challenges are twofold: most microbes remain uncultivable, and a persistent gap exists between field sampling and laboratory analyses. Here, we introduce the Advanced Mobile Laboratory (AML), a field-deployable platform that integrates confocal microscopy, image-enabled cell sorting, and cryo-preparation for expansion and electron microscopy. This setup enables immediate, standardized processing and analysis of environmental communities directly at the sampling site. We demonstrate its capability using marine eukaryotic plankton, showing how the AML enables multiscale investigations, from live imaging of natural communities to enabling ultrastructural and single-cell omics analyses, while minimizing sample degradation and enabling on-site experimentation. By bringing high-end sample preparation and analytical capacity into the field, the AML enables studying life in its natural context to mechanistically understand life's diversity in the environment.

Identifiers

PMID41889812
PMCPMC13015488

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.