ArticleJACS Au2026
Nickel-Catalyzed α‑Arylation and Alkenylation of α‑Trifluoromethyl Amines via 1,2-HAT Assisted by DMSO.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- Nickel-catalyzed hydroxymethylation with α-siliconChemical science · 2026Article
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Authors and funding
5 authors.
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Abstract
α-Trifluoromethyl amines are privileged scaffolds in pharmaceuticals and bioactive compounds, serving as metabolically stable amide bioisosteres. However, conventional synthetic approaches often suffer from multistep reactions, limited functional group tolerance, and instability of imine precursors. To overcome these limitations, we report a nickel-catalyzed cross-electrophilic coupling constructing diverse α-trifluoromethylamines via a mechanistically distinct pathway involving solvent-enabled 1,2-hydrogen atom transfer (HAT). In this process, the N-O bond is activated by Ni
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Registered trials
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