Evidence map›Paper›PMID 41889776›Full record

ArticleJACS Au2026

Ultrasound-Responsive Nanoparticles Enable Hydrophobic Antibiotic Release and Deep Penetration for Biofilm Treatment.

Maria L Odyniec, Daniel J Bell, Benjamin M Gallant, Rininta Firdaus, Grace Ball, Liam Hughes, Rebecca Oxtoby, Benjamin J Hewitt, Christopher M Williams, Asier R Muguruza and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Maria L OdyniecSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Daniel J BellSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Benjamin M GallantSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Rininta FirdausSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Grace BallSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Liam HughesSchool of Metallurgy and Materials, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Rebecca OxtobySchool of Biosciences, Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Benjamin J HewittSchool of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Christopher M WilliamsSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Asier R MuguruzaSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0003-4169-5024
Tim W OvertonSchool of Chemical Engineering, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Hung-Ji TsaiSchool of Biosciences, Institute of Microbiology and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Yu-Lung ChiuSchool of Metallurgy and Materials, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Dominik J KubickiSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0002-9231-6779
A Damien WalmsleySchool of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Sarah A KuehneSchool of Dentistry, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.
Zoe PikramenouSchool of Chemistry, College of Engineering and Physical Sciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, U.K.ORCID https://orcid.org/0000-0002-6001-1380

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Localized delivery of antibiotics is a promising strategy that leads to transformative treatment pathways of bacterial biofilms and increases the effectiveness of their administration in contrast to traditional delivery methods requiring high antibiotic doses. Hydrophobic antibiotics have poor activity against bacterial biofilms due to their limited penetration and are particularly challenging to deliver. Nanoparticles are ideal drug delivery agents to achieve spatially controlled delivery, but commonly their designs are either soft or porous, which limits temporally triggered release, with the result that most of the antibiotic does not reach deeply into the biofilm. In this study, we present designs of nonporous silica nanoparticles that encapsulate a lipophilic antibiotic, rifampicin, with noncovalent interactions and enable controlled release triggered by Low-Frequency Ultrasound (LFUS).

Indexed as

antibiotic releasecore@shellhydrophobic antibioticnanoparticlessilicaultrasound

Identifiers

PMID41889776
PMCPMC13014244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.