ArticleJACS Au2026
Discovering Serum Stable Protein-Protein Interaction Inhibitors with N‑Terminus-Capped Bicyclic Phage Libraries.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Protein-protein interactions (PPIs) play many important roles in physiology and disease, yet are often difficult to inhibit by synthetic molecules. Peptides are well-suited for targeting the typically large PPI interfaces because their intermediate size allows them to bind to broad protein surfaces with high specificity. Multicyclic peptide-based inhibitors are particularly appealing for their greater structural rigidity and increased resistance to proteolytic degradation. In this study, we utilized our recently described cysteine-directed proximity-driven bicyclization cross-linker, bischlorooxime
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