Evidence map›Paper›PMID 41889767›Full record

ArticleJACS Au2026

Amine-to-Halogen Exchange Enables an Amine-Acid Etherification.

Andrew McGrath, Sandip Kumar Das, Eunjae Shim, Andrew Outlaw, Serik Zhumagazy, Hamid Rashidi Nodeh, Jean-Francois Brazeau, Zhicai Shi, Jennifer D Venable, Christine Gelin and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Quaternary Carbons from Amines and Acids.Journal of the American Chemical Society · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Andrew McGrathDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0001-9275-0017
Sandip Kumar DasDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Eunjae ShimDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0002-4085-9659
Andrew OutlawDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Serik ZhumagazyDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Hamid Rashidi NodehDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.
Jean-Francois BrazeauTherapeutics Discovery, Johnson & Johnson Innovative Medicines, La Jolla, San Diego, California 92121, United States.
Zhicai ShiTherapeutics Discovery, Johnson & Johnson Innovative Medicines, La Jolla, San Diego, California 92121, United States.
Jennifer D VenableTherapeutics Discovery, Johnson & Johnson Innovative Medicines, La Jolla, San Diego, California 92121, United States.
Christine GelinTherapeutics Discovery, Johnson & Johnson Innovative Medicines, La Jolla, San Diego, California 92121, United States.ORCID https://orcid.org/0000-0001-5917-3588
Paul M ZimmermanDepartment of Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0002-7444-1314
Tim CernakDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States.ORCID https://orcid.org/0000-0001-5407-0643

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactions that form ethers are used broadly for pharmaceutical, fragrance, materials, and agrichemical applications. We report here an amine-acid etherification reaction that proceeds via a facile amine-halogen exchange and an ester-selective reduction. The method employs free aliphatic amines and carboxylic acids to form C-(sp

Indexed as

amine-acidC−O cross-couplingetherificationhalogenationhigh-throughput experimentation

Identifiers

PMID41889767
PMCPMC13014198

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.