Left-Handed Helices in DNA Nanotechnology.

Sangeetha Selvam, Johnsi Mathivanan, Arun Richard Chandrasekaran

Abstract readReview

In one paragraph

Review in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sangeetha SelvamThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States.ORCID https://orcid.org/0000-0002-3890-5126

Johnsi MathivananDepartment of Nanoscale Science and Engineering, University at Albany, State University of New York, Albany, New York 12222, United States.

Arun Richard ChandrasekaranThe RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States.ORCID https://orcid.org/0000-0001-6757-5464

Funding

Programmable DNA Nanostructures as Biomedical and Structural ScaffoldsR35GM150672 · NIGMS · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI Arun Richard Chandrasekaran · 2023 to 2026

$1.7M

NIGMS NIH HHS R35 GM150672

6 · The paper itself

Abstract

DNA nanotechnology involves the use of DNA as a material to build nanoscale shapes and structures. This strategy typically uses the conventional right-handed B-form DNA for nanoscale construction. In some cases, alternate nucleic acid structures, such as those that form left-handed helices, are used in the design and assembly of nanostructures. Creation of left-handed helices for nanostructures uses Z-DNA, a left-handed structure, or L-DNA strands that result in the formation of a left-handed duplex. In addition, structures that have a global left-handed helicity but underlying right-handed B-DNA units have also been created. This perspective discusses the left-hand helices used in DNA nanotechnology, their applications, and their future impact.

Indexed as

DNA double helixDNA nanotechnologyDNA origamiDNA topologyL-DNAleft-handed DNAZ-DNA

Identifiers

PMID41889750

DOI10.1021/jacsau.6c00027

PMCPMC13014259

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.