Evidence map›Paper›PMID 41889748›Full record

ArticleJACS Au2026

A Total Synthesis of (-)-Strychnine Using Photoredox Catalysis.

Rainer Wiechert, Leander Geske, Jasmin Hammes, Dogus Tuncer, Till Opatz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rainer WiechertDepartment of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, Mainz 55128, Germany.ORCID https://orcid.org/0009-0009-1385-4738
Leander GeskeDepartment of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, Mainz 55128, Germany.
Jasmin HammesDepartment of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, Mainz 55128, Germany.
Dogus TuncerDepartment of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, Mainz 55128, Germany.
Till OpatzDepartment of Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10-14, Mainz 55128, Germany.ORCID https://orcid.org/0000-0002-3266-4050

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A concise route toward (-)-strychnine is presented. Key steps include the photoredox-catalytic C2-cyanomethylation of Boc-l-Trp-OMe and a condensation-electrocyclization cascade linking two fragments convergently to obtain an advanced intermediate. A photochemical decarboxylation provided convenient access to strychnofluorine, which could be transformed through the Wieland-Gumlich aldehyde to strychnine. All building blocks can be traced back to renewable sources.

Indexed as

AlkaloidsCascade cyclizationPhotoredox catalysisRadical reactionsTotal synthesis

Identifiers

PMID41889748
PMCPMC13014235

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.