Flow Chemistry Enabled Asymmetric Total Synthesis of (+)-Biotin through Pseudocatalytic Strategy.

Xianjing Zheng, Liang Gao, Yajiao Zhang, Jiale Wu, Dang Cheng, Li Wan, Fener Chen

Abstract read

In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xianjing ZhengEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.

Liang GaoEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.

Yajiao ZhangEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.

Jiale WuEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.

Dang ChengEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.ORCID https://orcid.org/0000-0001-5899-5141

Li WanEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-9362-9806

Fener ChenEngineering Center of Catalysis and Synthesis for Chiral Molecules, Department of Chemistry, Fudan University, Shanghai 200433, China.ORCID https://orcid.org/0000-0002-6734-3388

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Continuous-flow chemistry has greatly expanded the capacity for tailored molecular construction, yet the multistep synthesis of natural products and small-molecule pharmaceuticals remains constrained by solvent and reagent incompatibilities, byproduct accumulation, reactor clogging, and mismatched time scales. Through the deliberate integration of multiple purpose-devised tubular continuous extractors, in-line liquid/liquid separators, fixed-bed drying units, and in-line waste-gas vent devices, we have established a fully coupled continuous-flow regime that enables the 13-step asymmetric total synthesis of (+)-biotin with a 43% overall yield and a total residence time of only 121.5 min. The process telescopes a newly developed chiral auxiliary-controlled desymmetrization to construct (3a

Indexed as

biotinclosed-loopflow synthesismultisteppseudocatalytic

Identifiers

PMID41889743

DOI10.1021/jacsau.5c01570

PMCPMC13014231

What OpenQuestion holds

Textmetadata

LicenceCC BY-NC-ND

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.