Evidence map›Paper›PMID 41889741›Full record

ArticleJACS Au2026

Targeted Discovery of β‑Branched Conjugated Polyketides from Bacteria Based on Genomic and Metabolomic Hallmarks.

Jinsheng Cui, Ilnam Kang, Haewon Lee, Bo Eun Heo, Suhyun Ye, Jayho Lee, Dong Hyun Moon, Eun Seo Bae, Chae Won Ock, Daniel Shin and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jinsheng CuiNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Ilnam KangDepartment of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea.
Haewon LeeNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Bo Eun HeoLaboratory for Bacterial Disease Control, Division of Life Science, Department of Bio & Medical Big Data (BK Four Program), Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
Suhyun YeDepartment of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
Jayho LeeNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Dong Hyun MoonNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Eun Seo BaeNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Chae Won OckNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Daniel ShinNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.
Joon Soo AnNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.ORCID https://orcid.org/0000-0002-3282-5790
Hahk-Soo KangDepartment of Biomedical Science and Engineering, Konkuk University, Seoul 05029, Republic of Korea.ORCID https://orcid.org/0000-0001-9602-6042
Sang Kook LeeNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.ORCID https://orcid.org/0000-0002-4306-7024
Ki-Bong OhDepartment of Agricultural Biotechnology, College of Agriculture and Life Sciences and Natural Products Research Institute, Seoul National University, Seoul 08826, Republic of Korea.
Illhwan ChoDepartment of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.
Hye Yun KimDepartment of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.ORCID https://orcid.org/0000-0003-3757-5652
YoungSoo KimDepartment of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon 21983, Republic of Korea.ORCID https://orcid.org/0000-0001-5029-7082
Jichan JangLaboratory for Bacterial Disease Control, Division of Life Science, Department of Bio & Medical Big Data (BK Four Program), Research Institute of Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea.
Jang-Cheon ChoDepartment of Biological Sciences and Bioengineering, Inha University, Incheon 22212, Republic of Korea.
Dong-Chan OhNatural Products Research Institute and Research Institute of Pharmaceutical Sciences, College of Pharmacy, Seoul National University, Seoul 08826, Republic of Korea.ORCID https://orcid.org/0000-0001-6405-5535

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A logical discovery method based on metabologenomic targeting was designed to search for new β-branched conjugated polyketides. PCR screening of a bacterial DNA library (1,638 strains) targeting the key enzyme hydroxymethylglutaryl-CoA synthase (HCS) homolog-encoding gene as a genomic hallmark identified 67 hit strains. Phylogenetic analysis of HCS homolog-encoding gene amplicons prioritized strains potentially producing new β-branched conjugated polyketides. Vibronic fine structures in ultraviolet spectra as a metabolomic hallmark clearly identified β-branched conjugated polyketides in bacterial extracts, logically leading to the discovery of paenillaene (

Indexed as

bioactive natural productshydroxymethylglutaryl-CoA synthasemetabologenomic targetingvibronic fine structureβ-branched conjugated polyketides

Identifiers

PMID41889741
PMCPMC13014233

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.