ArticleJACS Au2026
Host-Guest Assembly of Transmucosal Molecular Spherical Nucleic Acids for Oral Leukoplakia Immunotherapy and Microbiota Homeostasis Restoration.
Article in JACS Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Design of Spherical Nucleic Acids: From Fast Synthesis to Structural Engineering.Biomolecules · 2026Review
- Heterogeneous mechanisms, risk stratification, and translational advances in the malignant transformation of oral potentially malignant disorders to oral squamous cell carcinoma.Frontiers in molecular biosciences · 2026Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oral leukoplakia (OLK) is a prevalent oral mucosal disorder and is at risk of malignant transformation. While nanomedicines hold great promise for OLK therapy, their current nanoformulations for topical treatment of OLK typically suffer from poor transmucosal penetration, neglect immunomodulation for suppressing epithelial hyperproliferation, and lack insights into restoration of oral microbiota homeostasis. Herein, we leverage host-guest molecular recognition for the precise construction of an unprecedented molecular spherical nucleic acid (SNA), supramolecular SNA (sSNA). Briefly, β-cyclodextrin (β-CD) and indocyanine green are comodified on the spherical poly-(amidoamine) dendrimer. The β-CD-grafted dendrimers enable high-performance radial arrangement of ferrocene-tagged CpG immunoadjuvant and PD-L1 aptamer through host-guest recognition. The thus-formed sSNA-CpG/Apt
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Registered trials
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