ArticleFrontiers in nutrition2026
Low initial body fat percentage exacerbates skeletal muscle loss and increases the risk of hyperuricemia during high-altitude acclimatization in young men.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The incidence of hyperuricemia (HUA) increases significantly after individuals ascend to a high-altitude environment, particularly among young men. Previous studies have shown correlations between skeletal muscle mass, fat mass, and serum uric acid levels. However, whether changes in body composition under high-altitude conditions influence the occurrence of HUA has not been reported. Objectives: This study aimed to investigate the effects of initial body fat percentage (BF%) and changes in body composition on the development of HUA in young men after 1 year at high altitude. Methods: In this prospective observational study, 216 young men who relocated from a plain area to a high-altitude area for 1 year were enrolled. Data on basic information, body composition, and laboratory measurements were collected both before relocation and after the one-year period. Results: After 1 year at high altitude, skeletal muscle mass (SMM) decreased significantly. Linear regression analysis revealed that the change in SMM was correlated with the initial BF%; a lower initial BF% was associated with a more pronounced decrease in SMM ( Conclusion: Our findings indicate that for young men moving from plains to high altitudes, the BF% and the change in SMM can be used to predict the incidence of hyperuricemia after 1 year.
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