ReviewTherapeutics and clinical risk management2026
From Tradition to Future: Pathophysiological Mechanisms and Clinical Research Progress in the Treatment of Hypothyroidism with Traditional Chinese Medicine--A Narrative Review.
Review in Therapeutics and clinical risk management, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Hypothyroidism and Metabolic Dysfunction-Associated Steatotic Liver Disease: Mechanisms, Clinical Links, and Therapeutic Implications.Current obesity reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypothyroidism, a prevalent endocrine disorder primarily resulting from inadequate thyroid hormone secretion, is commonly attributed to etiologies, such as Hashimoto's thyroiditis and iodine deficiency. Currently, levothyroxine (LT4) replacement therapy is the standard treatment in Western medicine. However, suboptimal therapeutic responses in certain patients have motivated the investigation of alternative interventions. In recent years, TCM, particularly the integrative approach of combining acupuncture with herbal medicine, has demonstrated promising potential in the management of hypothyroidism. Through a systematic review of 12 randomized controlled trials (RCTs) onTCM for hypothyroidism conducted in the past decade, this article found that TCM exerts therapeutic effects by regulating immune function, improving thyroid antibody levels, and modulating metabolic status. Commonly used herbs include Astragalus membranaceus (Huangqi), Codonopsis pilosula (Dangshen), and Rehmannia glutinosa (Shudihuang), whose mechanisms of action involve key signaling pathways such as MAPK and PI3K-AKT.Acupuncture and moxibustion therapies target specific acupoints (e.g. Guanyuan and Zusanli) to improve thyroid function by regulating apoptosis and the associated signaling cascades. Multiple randomized controlled trials have demonstrated that the combination of acupuncture and herbal medicine not only significantly ameliorates clinical symptoms, but also modulates serum concentrations of TSH, T3, and T4, thereby enhancing treatment efficacy. Nonetheless, current research is limited by factors such as small sample sizes, insufficient long-term follow-up, and a lack of comprehensive mechanistic studies. Future investigations employing large-scale, multi-center, high-quality clinical trials are warranted to further substantiate the efficacy and safety of these integrative therapeutic modalities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.