ArticleFrontiers in public health2026
Defining success in functional cure for chronic hepatitis B: a nationwide survey of physician benchmarks to guide clinical practice and trial design.
Article in Frontiers in public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Background: While functional cure (FC) is the elusive endpoint of chronic hepatitis B (CHB) therapy, a clear consensus on its practical expectations is lacking. To inform the development of new treatments and clinical guidelines, we conducted a nationwide survey to quantify Chinese physicians' perceptions of FC and their benchmarks for successful novel therapies. Methods: In this cross-sectional study, we administered a detailed online questionnaire to 151 attending physicians and above with extensive experience treating CHB. A quota sampling method was employed to ensure a geographically balanced cohort representative of practice patterns across China. Results: A total of 151 physicians were surveyed, with the vast majority (70.8%) endorsing functional cure (FC) as the ultimate treatment goal. The most valued clinical benefit of FC was the reduction in liver cirrhosis and hepatocellular carcinoma (mean score 9.6/10). Combination therapy containing Peg-IFNα was favored by 76.1% of respondents as the preferred strategy to achieve FC. Post-treatment, physicians strongly recommended a minimum of one year of follow-up and adjunct consolidation therapy to mitigate relapse risk. Critically, a consensus emerged on key benchmarks for novel therapies: a minimal acceptable FC rate of 30% and a strong preference for regimens based on Nucleos(t)ide Analogs (NAs) and/or Peg-IFNα. Conclusions: Our findings translate the collective expertise of Chinese physicians into actionable benchmarks for HBV functional cure. The consensus on a minimal 30% cure rate and a preference for combination therapy provide crucial guidance for clinical trial design and the development of novel antiviral strategies.
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