ReviewJPRAS open2026
Liposomal versus standard bupivacaine for post-operative opioid requirements following abdominal-based breast reconstruction: A systematic review and meta-analysis.
Review in JPRAS open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Liposomal Bupivacaine in Perioperative Analgesia: A Comprehensive Review of Clinical Efficacy, Safety, and Economic Context.Current pain and headache reports · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Donor-site pain after abdominal-based autologous breast reconstruction affects opioid use and recovery. Liposomal bupivacaine (LB) delivered via the transversus abdominis plane (TAP) block may enhance analgesia compared with standard bupivacaine (SB), yet its added clinical benefit remains unclear. Methods: A systematic review and meta-analysis was conducted according to PRISMA 2020 and Cochrane guidelines. Databases searched included PubMed, Embase, and Cochrane Library. Studies comparing LB with SB for the TAP block were included. Outcomes included postoperative opioid consumption, pain scores, hospital length of stay (LOS), time to ambulation, and complications. Both pairwise and single-arm meta-analyses were performed using a random-effects model. Results: A total of twelve studies were included in the analysis, comprising 1,690 participants. Pairwise meta-analyses indicated a trend favoring the use of LB in relation to total opioid use (SMD, -0.17; 95% CI [-1.20, 0.86]; Conclusion: Liposomal bupivacaine appears safe and may offer modest recovery benefits in abdominal-based breast reconstruction. However, its incremental advantage over standard bupivacaine remains uncertain in ERAS-optimized settings. Selective use is recommended pending further high-quality trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.