Evidence map›Paper›PMID 41889528›Full record

ArticleFrontiers in medicine2026

Comparison of the efficacy of low, moderate and standard doses of rituximab in the treatment of membranous nephropathy.

Mengling Guo, Wenli Wan, Jiayue Li, Shun Wu, Zhenmin Ruan, Rui Wang, Zhaoyong Zhang, Xin Geng, Xueqing Hu, Hongqi Ren

Abstract read
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mengling Guo *Department of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Wenli Wan *Department of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Jiayue LiDepartment of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Shun WuDepartment of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Zhenmin RuanDepartment of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Rui WangDepartment of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Zhaoyong ZhangDepartment of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Xin GengDepartment of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Xueqing HuDepartment of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.
Hongqi RenDepartment of Nephrology, Huaihai Hospital Affiliated of Xuzhou Medical University, Xuzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Rituximab (RTX) is recommended as a first-line therapy for membranous nephropathy (MN); however, the efficacy of different dosing regimens remains controversial. This study aimed to evaluate and compare the efficacy of low-dose, moderate- and standard-dose RTX in treating MN. Methods: One hundred patients with MN who received RTX at the Affiliated Hospital of Xuzhou Medical University and Huaihai Hospital of Xuzhou Medical University between May 2021 and December 2024 were included. The patients were divided into three groups: a low-dose group ( Results: After 12 months of treatment, for 24 h-UTP, CD20 Conclusion: Three treatment regimens significantly reduced anti-PLA2R antibody titers and urinary protein levels, while increasing serum albumin, without a significant impact on renal function. The therapeutic efficacy of the three doses was comparable.

Indexed as

efficacylow dosemembranous nephropathymoderate doserituximabstandard dose

Identifiers

PMID41889528
PMCPMC13013044

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.