ArticleAnnals of African medicine2026
Persistent Postoperative Hypotension Following Total Hip Replacement in a Patient with Schizophrenia.
Article in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
abstractWe report the case of a middle-aged male patient with schizophrenia on long-term antipsychotic therapy who underwent a complex primary total hip replacement. The patient developed persistent postoperative hypotension despite stable intraoperative haemodynamics and no evidence of bleeding or hypovolaemia. Drug-induced vasodilation secondary to alpha-adrenergic blockade from first-generation antipsychotics was considered the most likely cause. Blood pressure responded promptly to metaraminol infusion. This case highlights the importance of recognising medication-related vasoplegia, maintaining a broad differential diagnosis for postoperative hypotension, and considering early vasopressor therapy and escalation of care when required.
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