ArticleComprehensive Physiology2026
Stratification of Motor Cortex Excitability to Transcranial Stimulation Uncovers Functional Network Differences in Healthy Older Adults as Revealed by Resting State EEG Functional Coupling in Brain Network.
Article in Comprehensive Physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUnderstanding the neural organization underlying motor function is essential for explaining individual differences in motor performance and the impact of aging.
methodsWe examined 87 healthy older adults who underwent, in different sessions, resting state electroencephalography (EEG) recordings and Transcranial Magnetic Stimulation (TMS) applied to the hand muscles representation area in the primary motor cortex to elicit Motor Evoked Potentials (MEPs). Furthermore, Mini-Mental State Examination (MMSE) and handgrip strength evaluations were carried out on subjects. Subjects were split into two groups, Low MEP (L-MEP) and High MEP (H-MEP) groups, based on individual MEP amplitude, and age, sex, and education matched. Functional connectivity was analyzed through Magnitude-Squared Coherence (MSCoh) and Total Coherence (TotCoh) in different frequency bands and brain regions of interest.
findingsThe L-MEP presented decreased MSCoh in the Alpha 2 and Beta 1 bands, and decreased TotCoh in the Alpha 2 band within the Temporal region as well as in the Beta 1 band across Parietal, Occipital, and Temporal regions. No significant difference in grip strength was found while the MMSE score of L-MEP group was significantly lower compared to the H-MEP one. These findings indicate that reduced motor cortex excitability reflects decreased network integration, particularly in regions associated with cognitive and sensorimotor processing. These findings may reflect early neurophysiological vulnerability.
conclusionsThese results underscore the resting state EEG as a non-invasive, highly sensitive tool monitoring subtle alterations in brain functional networks that may precede clinical symptoms, offering a powerful tool for monitoring and individualized intervention.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.