Evidence map›Paper›PMID 41889097›Full record

ArticleChemistry & biodiversity2026

Inhibitors of Sodium-Dependent Serotonin Transporter Protein (SERT) as Potential New Nematicides.

Geraldo Jamisse Hodela, Vitor Pereira de Sousa, Mariana Castro de Melo, Rodrigo Martins Fráguas, Willian César Terra, Denilson Ferreira de Oliveira

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Geraldo Jamisse HodelaDepartment of Chemistry, Federal University of Lavras, Lavras, MG, Brazil.ORCID https://orcid.org/0000-0002-1483-2452
Vitor Pereira de SousaDepartment of Phytopathology, Federal University of Lavras, Lavras, MG, Brazil.
Mariana Castro de MeloDepartment of Chemistry, Federal University of Lavras, Lavras, MG, Brazil.
Rodrigo Martins FráguasDepartment of Chemistry, Federal University of Lavras, Lavras, MG, Brazil.
Willian César TerraDepartment of Phytopathology, Federal University of Lavras, Lavras, MG, Brazil.
Denilson Ferreira de OliveiraDepartment of Chemistry, Federal University of Lavras, Lavras, MG, Brazil.ORCID https://orcid.org/0000-0001-9326-8716

Funding

Conselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado de Minas Gerais
6 · The paper itself

Abstract

Nematodes of the genus Meloidogyne cause major losses in agricultural production worldwide. To identify potentially useful chemical structures for developing new nematicides, this study initially aimed to determine in silico  - using computationally efficient techniques - the protein target of chaetoglobosins A and B in these nematodes. This process led to the selection of the sodium-dependent serotonin transporter protein (SERT). The activities of SERT inhibitors were subsequently evaluated in vitro. The best result was obtained with paroxetine, which caused 50% mortality (LC

Indexed as

Antinematodal AgentsSelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsTylenchoideaAnimalsDose-Response Relationship, DrugMolecular Docking SimulationMolecular StructureParoxetineStructure-Activity RelationshipSulfonesThiazolesAntinematodal AgentsfluensulfoneParoxetineSelective Serotonin Reuptake InhibitorsSerotonin Plasma Membrane Transport ProteinsSulfonesThiazolesMeloidogynemolecular dockingnematicideparoxetinesodium‐dependent serotonin transporter

Identifiers

PMID41889097
PMCPMC13022468

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.