SynthesisInternational dental journal2026
Periodontal Disease and Incidence of Cancers: A Systematic Review and Meta-analysis of Cohort Studies.
Synthesis in International dental journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Risk of cancer in periodontal disease: an umbrella review of meta-analyses.Frontiers in immunology · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Associations between periodontal disease (PD) and cancers risk have been described previously, but the evidence remains inconclusive. This study aimed to investigate the association between PD and specific cancers through a systematic review and meta-analysis. We searched PubMed and Web of Science for English-language studies. Prospective and retrospective cohort studies were included. Three reviewers independently assessed study eligibility, extracted data, and evaluated the quality of studies. Random or fixed effects models were used to assess the association between PD and cancers. Stratified analyses by PD assessment methods, follow-up duration, and geographic region were conducted. A total of 8816 articles were identified, and 26 cohort studies met the inclusion criteria. Positive association between PD and multiple cancers, including pancreatic cancer (RR = 1.26, 95% CI: 1.03-1.52), bladder cancer (RR = 1.21, 95% CI: 1.11-1.32), esophageal cancer (RR = 1.34, 95% CI: 1.04-1.71), prostate cancer (RR = 1.17, 95% CI: 1.07-1.29), colorectal cancer (RR = 1.16, 95% CI: 1.01-1.34), gastric cancer (RR = 1.16, 95% CI: 1.08-1.25), and breast cancer (RR = 1.11, 95% CI: 1.03-1.17). Stratified by PD assessment methods, self-reported PD was positively associated with colorectal cancer (RR = 1.28, 95% CI: 1.01-1.62), gastric cancer (RR = 1.34, 95% CI: 1.11-1.63), lung cancer (RR = 1.19, 95% CI: 1.09-1.31), bladder cancer (RR = 1.26, 95% CI: 1.12-1.43), and pancreatic cancer (RR = 1.42, 95% CI: 1.03-1.96). Clinically examined PD only linked to gastric cancer (RR = 1.11, 95% CI: 1.04-1.16). PD was associated with colorectal, gastric, bladder, pancreatic, esophageal, and breast cancers. Self-reported and clinically examined PD differed slightly in effect magnitudes, yet the direction of associations remained consistent.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.