ArticleBiological research2026
Reelin regulates the migration and differentiation of extravillous trophoblastic cells.
Article in Biological research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundApoER2/LRP8 is a receptor highly expressed in the placenta; however, its physiological role in this organ remains poorly understood. The VLDL receptor has been less studied in the placenta. Reelin, a relevant ligand for both receptors, is an extracellular glycoprotein that participates in neuronal polarization, migration and differentiation, hence having a central role in the central nervous system (CNS) development. Reelin triggers a complex signaling pathway that regulates cytoskeleton dynamics, cell migration, differentiation and gene expression. This paper aimed to determine whether the Reelin signaling pathway plays a role in cellular processes involved in placentation.
resultsReelin receptors ApoER2 and VLDLR were found in first-trimester extravillous trophoblast (EVT) cell lines. EVT cells Swan 71 responded to Reelin exposure by activating PI3K-Akt and increasing ApoER2 protein levels, but not VLDLR. Additionally, a dual role for Reelin via PI3K was established in these cells, as it enhanced trophoblastic migration at 2% O2 (to mimic the hypoxic physiologic conditions of trophoblastic migration) and promoted differentiation to an endothelial-like phenotype at 21% O2. Migration was also stimulated, independent of PI3K, when cells were exposed to normoxic (21% O2) or chemically induced hypoxic (CoCl2) conditions. We propose that, physiologically, during the first trimester, Reelin, together with its receptors, could stimulate trophoblastic migration and differentiation. Interestingly, under hypoxia, ApoER2 and VLDLR protein levels were increased, and Reelin modulated hypoxia-inducible factor HIF1-α levels. ApoER2, VLDLR and Reelin were detected in human term placentas from normal and pre-eclampsia with severe features (PE-SF) pregnancies. In the plasma of first-trimester pregnant women, Reelin levels were lower in patients with severe preeclampsia (PE) at a time before the onset of PE clinical symptoms.
conclusionsReelin could be involved in placentation, playing roles in EVT migration and differentiation. The reduction in maternal Reelin levels detected early in pregnancy could be a potential biomarker for PE.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.