Evidence map›Paper›PMID 41888915›Full record

ArticleVirology journal2026

Mechanistic characterization of the antiviral effects of nordihydroguaiaretic acid against West Nile virus.

Florencia Martinez, Lucia M Ghietto, Giuliana Lingua, Pedro I Gil, Juan J Aguilar, Tomas I Gomez, Juliana Marioni, Susana C Núñez-Montoya, Brenda S Konigheim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Virology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Florencia Martinez *Instituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gomez S/N. Cdad. Universitaria, X5000HUA Córdoba,, Córdoba, Argentina.
Lucia M Ghietto *Instituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gomez S/N. Cdad. Universitaria, X5000HUA Córdoba,, Córdoba, Argentina.
Giuliana LinguaInstituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gomez S/N. Cdad. Universitaria, X5000HUA Córdoba,, Córdoba, Argentina.
Pedro I GilInstituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gomez S/N. Cdad. Universitaria, X5000HUA Córdoba,, Córdoba, Argentina.
Juan J AguilarInstituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gomez S/N. Cdad. Universitaria, X5000HUA Córdoba,, Córdoba, Argentina.
Tomas I GomezInstituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gomez S/N. Cdad. Universitaria, X5000HUA Córdoba,, Córdoba, Argentina.
Juliana MarioniDepartamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende. Cdad Universitaria. X5000HUA Córdoba,, Córdoba, Argentina.
Susana C Núñez-MontoyaDepartamento de Ciencias Farmacéuticas, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Haya de la Torre y Medina Allende. Cdad Universitaria. X5000HUA Córdoba,, Córdoba, Argentina.
Brenda S KonigheimInstituto de Virología "Dr. J. M. Vanella", Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Enfermera Gordillo Gomez S/N. Cdad. Universitaria, X5000HUA Córdoba,, Córdoba, Argentina. brenda.konigheim@unc.edu.ar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mosquito-borne arboviruses, such as West Nile virus (WNV), pose a global health threat and currently lack approved antiviral therapies. This unmet medical need underscores the importance of identifying novel therapeutic agents, with natural products emerging as promising candidates. Nordihydroguaiaretic acid (NDGA), a natural lignan from Larrea spp., is a known broad-spectrum antiviral. This study aimed to characterize the antiviral activity of NDGA against WNV and elucidate its mechanism of action, focusing on host cellular factors. Using plaque reduction and immunofluorescence assays in LLC-MK2 cells, we demonstrated that NDGA inhibits WNV replication with an EC

Indexed as

Antiviral AgentsMasoprocolWest Nile virusAnimalsCell LineViral Plaque AssayVirus InternalizationVirus ReplicationAntiviral AgentsMasoprocolAntiviral activityArbovirusesCytoskeletonLignanNatural product

Identifiers

PMID41888915
PMCPMC13147777

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.