S100A8/A9-amplified inflammation (TNF-α/IL-1β) in the bone marrow of tumor-bearing host disrupts early B cell development.

Pan Yang, Hao Wen, Xiaoling Chen, Meiling Yu, Haili Yu, Liang Gong, Lintao Zhao, Li Wang

Abstract read

In one paragraph

Article in Cell & bioscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Pan Yang *Department of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, No. 30 Gaotan Yanzheng Street, Chongqing, 400038, China.

Hao Wen *Institute of Immunology PLA, Army Medical University, No. 30 Gaotan Yanzheng Street, Chongqing, 400038, China.

Xiaoling Chen *Institute of Immunology PLA, Army Medical University, No. 30 Gaotan Yanzheng Street, Chongqing, 400038, China.

Meiling YuInstitute of Immunology PLA, Army Medical University, No. 30 Gaotan Yanzheng Street, Chongqing, 400038, China.

Haili YuBiomedical Analysis Center PLA, Army Medical University, Chongqing, 400038, China.

Liang GongDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, No. 30 Gaotan Yanzheng Street, Chongqing, 400038, China. gongliang@tmmu.edu.cn.

Lintao ZhaoDepartment of Respiratory and Critical Care Medicine, First Affiliated Hospital of Army Medical University, No. 30 Gaotan Yanzheng Street, Chongqing, 400038, China. zhao72@tmmu.edu.cn.ORCID http://orcid.org/0000-0002-0438-5126

Li WangInstitute of Immunology PLA, Army Medical University, No. 30 Gaotan Yanzheng Street, Chongqing, 400038, China. liwang118@tmmu.edu.cn.

Funding

National Nature Science Foundation of China No. 82073169

6 · The paper itself

Abstract

Solid tumors induce systemic immune suppression, including impaired B lymphopoiesis in the bone marrow (BM). This study elucidates a novel mechanism by which remote tumors disrupt early B cell development. We demonstrate that tumor-bearing hosts exhibit skewed BM hematopoiesis favoring myeloid lineages at the expense of lymphoid lineages, specifically B cells. This impairment originates at the Common Lymphoid Progenitors (CLPs) stage. Mechanistically, monocytes, particularly CXCR2⁺ monocytes within the BM of tumor bearing mice leads to significantly elevated secretion of inflammatory cytokines TNF-α and IL-1β. These cytokines suppress CLPs differentiation into B cells. Furthermore, the enhanced secretion of TNF-α and IL-1β is mainly amplified by elevated levels of myeloid-derived S100A8/A9 proteins in the tumor-bearing BM microenvironment. Collectively, these findings identify the S100A8/A9 / TNF-α/IL-1β axis as a critical pathway disrupting B lymphopoiesis in cancer, revealing potential therapeutic targets to restore immune competence and improve immunotherapy responses.

Identifiers

PMID41888897

DOI10.1186/s13578-026-01565-4

PMCPMC13141364

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LicenceCC BY-NC-ND

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.