Evidence map›Paper›PMID 41888880›Full record

ArticleSkeletal muscle2026

A Pax7::Foxo1 conditional mouse strain.

G Roger Askew, Jonathan Gauntlett, Katherine Brechun, Harald Kranz, Nicholas Salters, Jess D Tate, Ellen Wang, Cassie Badger, Shireen Elhabian, Jared Schnider and 4 more

Abstract read
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In one paragraph

Article in Skeletal muscle, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

G Roger AskewOzgene, Ozgene Pty. Ltd, Bentley, WA, 6983, Australia.
Jonathan GauntlettOzgene, Ozgene Pty. Ltd, Bentley, WA, 6983, Australia.
Katherine BrechunGen-H Genetic Engineering Heidelberg GmbH, Heidelberg, Germany.
Harald KranzGen-H Genetic Engineering Heidelberg GmbH, Heidelberg, Germany.
Nicholas SaltersChildren's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Jess D TateScientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Ellen WangChildren's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Cassie BadgerChildren's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Shireen ElhabianDepartment of Computer Science, Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, UT, 84112, USA.
Jared SchniderChildren's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Gillian St JohnChildren's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Samuel V RasmussenChildren's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Narendra BharathyChildren's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA.
Charles KellerChildren's Cancer Therapy Development Institute, 9025 NE Von Neumann Drive Ste 110, Hillsboro, OR, 97006, USA. charles@cc-tdi.org.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe PAX7::FOXO1 subtype of alveolar rhabdomyosarcoma (aRMS) is both understudied and an unmet clinical need. The biology of PAX7::FOXO1 aRMS is significantly different than PAX3::FOXO1 aRMS, presenting an opportunity to gain biological, clinical and therapeutic insights by murine genetic modeling of Pax7::Foxo1 for comparison to the existing conditional genetic mouse model of Pax3::Foxo1 aRMS.

methodsUsing gene targeting, a mouse strain harboring a Cre-LoxP activated conditional knock-in of Pax7::Foxo1 targeted to the murine Pax7 locus has been generated.

resultsActivation of the conditional knock-in of Pax7::Foxo1 allele in the prenatal Pax7 lineage recapitulates the birth defects (stunting and maxillofacial deformities) known for the conditional knock-in of Pax3::Foxo1 allele. Activation of the conditional knock-in of Pax7::Foxo1 allele in the prenatal Myf6 lineage is viable, fertile, and results in ongoing expression from Pax7 promoter in myofibers.

conclusionsThis mouse strain is a resource for the rhabdomyosarcoma research community to explore lineage (cell) of origin, to define sufficiency for tumor initiation or the necessity of cooperative tumor initiating mutations, to uncover the biology of the PAX7::FOXO1 subtype of alveolar rhabdomyosarcoma, and to test therapies including immunotherapies.

Indexed as

Forkhead Box Protein O1Forkhead Transcription FactorsPAX7 Transcription FactorRhabdomyosarcoma, AlveolarAnimalsDisease Models, AnimalFemaleGene Knock-In TechniquesMiceMice, TransgenicForkhead Box Protein O1Forkhead Transcription FactorsFoxo1 protein, mousePax7 protein, mousePAX7 Transcription FactorFoxo1Genetically-engineered mouse modelPax3Pax3:Foxo1Pax7Pax7:Foxo1Rhabdomyosarcoma

Identifiers

PMID41888880
PMCPMC13147794

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.