Evidence map›Paper›PMID 41888852›Full record

ArticleRespiratory research2026

A longitudinal study of quantitative pulmonary dynamic contrast enhanced MRI following COVID-19 infection.

Adrienne E Campbell-Washburn, Shreya Kanth, Matthew D Thurston, Christine Mancini, Kendall J O'Brien, Amanda Potersnak, Haiyan Wang, Julio Huapaya, David Regenold, Scott Baute and 2 more

2 registry-linked trialsAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03331380 narecruitingnot on this map

Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System

TypeinterventionalSponsorNational Heart, Lung, and Blood Institute (NHLBI)Ran2018 to 2028Enrolled2,950ConditionsCADArmsMRI scan - obj 1, MRI scans - obj 2, MRI scans - obj 3, MRI scans - obj 4
NCT04401449 completednot on this map

Cardiopulmonary Inflammation and Multi-System Imaging During the Clinical Course of COVID-19 Infection in Asymptomatic and Symptomatic Persons (COVID ARC 19)

TypeobservationalSponsorNational Institutes of Health Clinical Center (CC)Ran2020 to 2023Enrolled202ConditionsAcute and Long Term Effects of COVID-19 on Systemic Inflammation, Acute and Long Term Effects of COVID-19 on Lung Function, Acute and Long Term Effects of COVID-19 on Cardiac Function, Acute and Long Term Effects of COVID-19 on Kidney Function
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Adrienne E Campbell-WashburnCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD, 20892, United States. adrienne.campbell@nih.gov.
Shreya KanthCritical Care Medicine and Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, USA.
Matthew D ThurstonCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD, 20892, United States.
Christine ManciniCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD, 20892, United States.
Kendall J O'BrienCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD, 20892, United States.
Amanda PotersnakCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD, 20892, United States.
Haiyan WangCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD, 20892, United States.
Julio HuapayaCritical Care Medicine and Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, USA.
David RegenoldCritical Care Medicine Department, Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, USA.
Scott BauteCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD, 20892, United States.
Ahsan JavedCardiovascular Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Drive, Building 10 Rm B1D219, Bethesda, MD, 20892, United States.
Anthony F SuffrediniCritical Care Medicine and Pulmonary Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, National Institutes of Health, 10 Center Dr, Bethesda, MD, 20892, USA.

Funding

Proton and hyperpolarized xenon pulmonary MRI at 0.55TU01HL178354 · NHLBI · UNIVERSITY OF VIRGINIA · PI Adrienne Campbell, CRAIG H MEYER · 2025 to 2026
$1.2M
NHLBI NIH HHS Intramural Targeted Anti-COVID-19 ProgramNHLBI NIH HHS U01 HL178354NHLBI NIH HHS Z01-HL006257
6 · The paper itself

Abstract

backgroundChanges in pulmonary microvascular perfusion after SARS-CoV-2 infection remains poorly characterized due to limitations in longitudinal imaging. To provide a longitudinal evaluation of lung perfusion, we used quantitative dynamic contrast enhanced MRI (DCE-MRI) on a 0.55T MRI system in patients following COVID-19.

methodsIn this prospective study, we performed quantitative DCE-MRI to generate perfusion maps on patients with a history of COVID-19 between June 2020 and June 2023. Imaging studies were divided into acute, recovery, convalescent, and extended study phases, collected over 3 years. Median lung perfusion, perfusion heterogeneity, perfusion defect percent, pulmonary transit time, arterial transit time, and transit time defect percent were measured. Perfusion metrics were correlated with pulmonary function tests (PFT), disease severity, cardiorespiratory symptoms, vaccine status, viral variant, and chest CT findings.

resultsWe included 84 post-COVID-19 patients and 156 separate DCE-MRI exams for analysis, and 10 healthy volunteers. Statistical significance between patients with COVID-19 and healthy volunteers was observed for perfusion defect percent in all study phases (p < 0.01). Five patients had visible perfusion defects. Lower median perfusion was found in patients with low diffusing capacity for carbon monoxide (DLCO) in the recovery phase (p = 0.02), and patients with heterogeneous perfusion maps in the acute phase were more likely to have low DLCO at their final PFT measurements (p = 0.01). During the convalescent phase, patients with residual symptoms had lower median perfusion (p = 0.01), unvaccinated patients had higher transit time defect percent (p = 0.0047), and ground glass opacities on CT were associated with lower median perfusion (p = 0.004).

conclusionsPulmonary microvascular perfusion abnormalities are found months after COVID-19, with correlative findings in patients with persistence of pulmonary symptoms and impaired pulmonary function. Our findings further support the utilization of DCE-MRI in a broad range of pulmonary vascular disorders.

trial registrationclinicaltrials.gov NCT04401449 (registered 2020-05-22) and NCT03331380 (registered 2017-11-02).

Indexed as

COVID-19LungPulmonary CirculationAdultAgedContrast MediaDynamic Contrast Enhanced Magnetic Resonance ImagingFemaleHumansLongitudinal StudiesMaleMiddle AgedPerfusion Magnetic Resonance ImagingPost-Acute COVID-19 SyndromeProspective StudiesSARS-CoV-2Contrast MediaCOVID-19Dynamic-contrast enhancedMRIPerfusionSARS-CoV-2

Identifiers

PMID41888852
PMCPMC13244964

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.