Evidence map›Paper›PMID 41888802›Full record

Trial reportBMC oral health2026

Evaluating the effect of xylitol wipes on cariogenic bacteria in infants and toddlers: a longitudinal clinical trial.

Laila M El-Habashy, Omar Abd El Sadek El Meligy, Aliaa Abdelsalam Hamouda

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07245433 (Evaluating the Effect of Xylitol Wipes on Cariogenic Bacteria in Infants and Toddlers), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07245433 nacompletednot on this map

Evaluating the Effect of Xylitol Wipes on Cariogenic Bacteria in Infants and Toddlers: A Longitudinal Clinical Trial

TypeinterventionalSponsorAlexandria UniversityRan2024 to 2025Enrolled20ConditionsEarly Childhood Caries (ECC), Dental Caries Prevention, Oral Bacterial Colonization, Pediatric Oral HealthArmsXylitol Dental Wipes
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Laila M El-HabashyPediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Alexandria, 21131, Egypt.
Omar Abd El Sadek El MeligyPediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Alexandria, 21131, Egypt. omar.elmeligi@dent.alex.edu.eg.
Aliaa Abdelsalam HamoudaPediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Alexandria University, Alexandria, 21131, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundXylitol is widely used in caries prevention and has been shown to reduce cariogenic activity in children. However, limited evidence exists regarding the effectiveness of xylitol wipes in infants and toddlers.

objectiveTo investigate the effect of xylitol wipes on cariogenic activity in infants and toddlers. MATERIALS AND

methodsThis prospective, longitudinal, single–arm interventional study included 20 healthy, caries–free children aged 9 months to 1.5 years. Mothers were instructed to wipe their children’s teeth with xylitol wipes (Spiffies Baby Tooth Wipes™) three times daily for four weeks. Salivary samples were collected at baseline and weekly follow–up visits. Cariogenic activity was assessed by measuring lactic acid production using a chairside kit (Clinpro Cario L–Pop), and salivary mutans streptococci (MS) levels were determined using the CRT bacteria caries risk test.

resultsA highly significant reduction in salivary lactic acid levels was observed after one week of xylitol wipe use (P < 0.0001). A significant reduction in MS counts was observed by the fourth week (P = 0.02).

conclusionsDaily application of xylitol wipes reduced cariogenic activity in young children, suggesting that this delivery method may be a practical preventive approach during early childhood.

trial registrationThis trial was registered at ClinicalTrials.gov (Identifier: NCT07245433) on 14 November 2025.

Indexed as

Cariostatic AgentsDental CariesStreptococcus mutansSweetening AgentsXylitolBacterial LoadChild, PreschoolFemaleHumansInfantLactic AcidLongitudinal StudiesMaleProspective StudiesSalivaCariostatic AgentsLactic AcidSweetening AgentsXylitolClinical trialEarly childhood cariesLactic acidMutans streptococciXylitol wipes

Identifiers

PMID41888802
PMCPMC13063904

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.