Evidence map›Paper›PMID 41888748›Full record

ArticleBMC public health2026

HOme-based self-sampling for cervical cancer prevention education among women living with HIV in Ghana (HOPE-inG): study protocol for a cluster-randomized type 2 hybrid effectiveness implementation trial.

Matthew Asare, Nadia Adjoa Sam-Agudu, Obed Cudjoe, Emily Frueh, Karen Awura-Adjoa Ronke Coker, Alex Boadi Dankyi, Sebastian Ken-Amoah, Patrick Kafui Akakpo, Nancy Innocentia Ebu Enyan, Rodney X Sturdivant and 3 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06800664 (The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention Among Women Living With HIV in Ghana), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06800664 narecruitingnot on this map

The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention Among Women Living With HIV in Ghana (HOPE-inG): A Type 2 Hybrid Effectiveness Implementation Trial

TypeinterventionalSponsorBaylor UniversityRan2025 to 2029Enrolled1,500ConditionsCervical Cancer Screening, HIV, Self-sampling, Implementation ScienceArmsHealth providers and management at IG sites will receive ISS (i.e., management support, capacity-building, and social network support) and training on the HOPE implementation plan, Control Group
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Matthew Asare *Department of Public Health, Robbins College of Health and Human Sciences, Baylor University, Bear Place, PO Box 1, Waco, TX, USA. matt_asare@baylor.edu.
Nadia Adjoa Sam-Agudu *Global Pediatrics Program, Department of Pediatrics, University of Minnesota Medical School, 717 Delaware Street SE, Minneapolis, MN, 55455, USA.
Obed CudjoeDepartment of Medical Laboratory Science, School of Allied Health Sciences, College of Health and Allied Sciences, University of Cape Coast, University Post Office, Cape Coast, Ghana.
Emily FruehRobbins College of Health and Human Sciences, Baylor University, PO Box 1 Bear Place, Waco, TX, USA.
Karen Awura-Adjoa Ronke CokerGlobal Pediatrics Program, Department of Pediatrics, University of Minnesota Medical School, 717 Delaware Street SE, Minneapolis, MN, 55455, USA.
Alex Boadi DankyiDirectorate of Research, Innovation and Consultancy, University of Cape Coast, University Post Office, Cape Coast, Ghana.
Sebastian Ken-AmoahDepartment of Obstetrics and Gynecology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, University Post Office, Cape Coast, Ghana.
Patrick Kafui AkakpoDepartment of Pathology, School of Medical Sciences, University of Cape Coast, University Post Office, Cape Coast, Ghana.
Nancy Innocentia Ebu EnyanDepartment of Public Health Nursing, School of Nursing and Midwifery, College of Health and Allied Sciences, University of Cape Coast, University Post Office, Cape Coast, Ghana.
Rodney X SturdivantDepartment of Statistical Science, College of Arts & Sciences, Baylor University, 1 Bear Place, 97344, Waco, TX, 76798, USA.
Emmanuel Ekow AsmahDepartment of Data Science and Economic Policy, School of Economics, College of Humanities and Legal Studies, University of Cape Coast, University Post Office, Cape Coast, Ghana.
Gloria F Nuer-AllornuvorDepartment of Obstetrics and Gynecology, Cape Coast Teaching Hospital, P. O. Box CT 1363, Cape Coast, Ghana.
Dorcas Obiri-YeboahDepartment of Microbiology and Immunology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, University Post Office,, Cape Coast, Ghana.

Funding

The Impact of an Evidence-Based, Behavioral Cervical Cancer Screening Intervention among Women Living with HIV in Ghana (HOPE-inG): A Type 2 Hybrid Effectiveness Implementation TrialU01CA294757 · NCI · BAYLOR UNIVERSITY · PI Matthew Asare, Dorcas Obiri-Yeboah · 2024 to 2026
$1.4M
NCI NIH HHS U01 CA294757
6 · The paper itself

Abstract

backgroundWomen living with HIV (WLWH) are six times more likely to develop cervical cancer (CC) than women without HIV, underscoring the urgent need for early and frequent screening. In Ghana, however, screening uptake among WLWH remains critically low and no national screening program exists. The HOPE (HOme-based self-sampling Prevention Education) toolkit has proven effective in increasing screening uptake. HOPE-inG (HOPE 2.0 in Ghana) aims to adapt the HOPE toolkits and develop implementation support strategies (ISS) to enhance the uptake and sustainment of cervical screening within HIV care services.

methodsThis study will be conducted in four HIV clinics in Ghana's Central Region using a three-phase design. Preparation Phase (Year 1): Use mixed methods, including nominal group techniques with 40-60 stakeholders (WLWH, healthcare providers, policymakers), to prioritize ISS and refine HOPE into HOPE 2.0 or HOPE-inG. Implementation Phase (Years 2-3): Conduct a hybrid type 2 cluster-randomized controlled trial, comparing HOPE 2.0 + ISS (intervention group) versus HOPE 2.0 alone (control group). A total of 1,152 WLWH and 80 health providers will be enrolled. Sustainment Phase (Years 3-5): Evaluate the long-term sustainment of HOPE 2.0 and ISS using quantitative and qualitative methods. Primary outcomes include patient-level screening and treatment uptake (effectiveness) and provider-level implementation metrics (adoption, cost, fidelity, penetration and sustainability). Data sources include surveys, interviews, electronic tracking and fidelity checklists at multiple organizational levels. Cost analyses will employ micro-costing methods, and fidelity will be monitored through structured observations and log sheets. DISCUSSION: HOPE-inG is designed to develop scalable, sustainable strategies for improving cervical screening and care among WLWH in Ghana. By embedding evidence-based screening tools within HIV care services and supporting providers with targeted ISS, this study seeks to bridge critical gaps in cervical cancer prevention. Findings will provide evidence to inform national policy and guide the broader implementation of patient-driven and community-based screening programs in other low-resource settings, ultimately improving health outcomes and reducing disparities for WLWH.

trial registrationClinicalTrials.gov NCT06800664. Registered on 29 January 2025.

Indexed as

HIV InfectionsUterine Cervical NeoplasmsAdultEarly Detection of CancerFemaleGhanaHumansRandomized Controlled Trials as Topic3R model, Cervical cancerGhana, HIV infections, Health educationHIVHPVWomen

Identifiers

PMID41888748
PMCPMC13054973

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.