ArticleBMC infectious diseases2026
Association between reduced kidney function and tuberculosis treatment outcomes.
Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Tuberculosis-Related Hospitalization According to Comorbidity Burden: A Retrospective Single-Center Cohort Study.Tropical medicine and infectious disease · 2026Article
- Estimated Glomerular Filtration Rate and Associated Factors Prior to Anti-Tuberculosis Initiation Among Tuberculosis Patients at Bale Zone Hospitals Southeast Ethiopia: A Cross-Sectional Study Design.Infection and drug resistance · 2026Article
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Authors and funding
19 authors.
Funding
Abstract
backgroundThe association between kidney function and tuberculosis treatment outcomes remains uncertain.
methodsWe analyzed a multicenter prospective cohort of adults with rifampicin-susceptible pulmonary tuberculosis enrolled in Korea between 2019 and 2021. Kidney function was categorized using baseline estimated glomerular filtration rate (eGFR) calculated with the 2021 CKD-EPI creatinine equation and grouped as preserved (eGFR ≥ 60 mL/min/1.73 m²) and reduced (eGFR < 60 mL/min/1.73 m²) kidney function. An additional analysis evaluated severely reduced kidney function (eGFR < 30 mL/min/1.73 m²). The primary endpoint was unfavorable outcome, defined as loss-to-follow-up, treatment failure, death, still-on-treatment, transfer to another treatment unit, or recurrence, analyzed using multivariable logistic regression. The secondary endpoint was failure to complete treatment within 9 months of initiation, analyzed by Cox proportional hazards model. All models adjusted for prespecified covariates, with age and sex included in all models.
resultsAmong 966 participants, 89 (9%) had reduced kidney function. Unfavorable outcomes were more frequent among participants with reduced kidney function (41% vs. 19%; P < 0.001). After multivariable adjustment, reduced kidney function was independently associated with unfavorable outcomes (adjusted odds ratio [aOR], 2.46; 95% confidence interval [CI], 1.49-4.02). Severely reduced kidney function showed higher odds of unfavorable outcome (aOR, 5.52; 95% CI, 2.42-13.01). Reduced kidney function was associated with failure to complete treatment within 9 months (adjusted hazard ratio, 3.07; 95% CI, 1.69-5.59).
conclusionsReduced kidney function was independently associated with unfavorable TB treatment outcomes. Patients with impaired kidney function at the time of tuberculosis diagnosis may require closer clinical monitoring during treatment.
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