ArticleCommunications biology2026
KRT17 promotes triple negative breast cancer through activation of Wnt signaling and γδ T-cells recruitment.
Chermakani Panneer Selvam, Gatha Thacker, Ukjin Kim, Youley Tjendra, Melinda M Boone, Samantha Henry, Camila O Dos Santos, Rumela Chakrabarti
Abstract read
In one paragraphArticle in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Chermakani Panneer SelvamSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Ukjin KimSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Youley TjendraDepartment of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL, USA.
Melinda M BooneSylvester Comprehensive Cancer Center, University of Miami, Miami, FL, USA.
Samantha HenryCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Camila O Dos SantosCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Funding
Probing the role of epigenomics in Brca1-deficient mammary tumors.R01CA248158 · NCI · COLD SPRING HARBOR LABORATORY · PI DOS SANTOS, CAMILA · 2020 to 2024
$2.2MBlockade of cMYC oncogenic function by pregnancy-induced alterations and remodeling of the mammary glandR01CA284630 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Camila dos Santos · 2023 to 2026
$1.9MDeciphering the function of DNp63 and MDSCs in tumor promotion and metastasis of TNBCsR01CA237243 · NCI · UNIVERSITY OF PENNSYLVANIA · PI CHAKRABARTI, RUMELA · 2019 to 2023
$1.8MDefining the cellular and molecular effects of aging and age of pregnancy on breast tissue homeostasis and cancer initiationR01AG069727 · NIA · COLD SPRING HARBOR LABORATORY · PI DOS SANTOS, CAMILA · 2020 to 2024
$1.8MAmerican Cancer Society (American Cancer Society, Inc.) CSCC-Team-23-978452-01-CSCCBreast Cancer Research Foundation (BCRF) NXTGN-25-004NCI NIH HHS R01 CA248158NCI NIH HHS R01 CA284630NIA NIH HHS R01 AG069727U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) 1R01CA284630U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) R01 AG069727-01U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) R01CA237243U.S. Department of Health & Human Services | NIH | NCI | Division of Cancer Epidemiology and Genetics, National Cancer Institute (National Cancer Institute Division of Cancer Epidemiology and Genetics) R01CA248158-01
6 · The paper itselfAbstract
Triple-negative breast cancer (TNBC) is a very aggressive form of breast cancer and Black American (BA) women face disproportionately higher mortality rates than White American (WA) women. The molecular mechanism behind this disparate clinical outcome remains poorly understood. We find that BA TNBC patients exhibit higher protein expression of KRT17 compared to WA TNBC and non-TNBC patients and correlates to poor distant metastasis-free survival. Mechanistic studies in metastatic mouse TNBC tumors with higher Krt17 demonstrates higher Wnt signaling targets, cancer stem cells (CSCs), which positively correlates to several metastasis signatures, supporting clinical data. Consistently, KRT17
Indexed as
Keratin-17Receptors, Antigen, T-Cell, gamma-deltaTriple Negative Breast NeoplasmsWnt Signaling PathwayAnimalsCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMiceNeoplastic Stem CellsKeratin-17KRT17 protein, humanReceptors, Antigen, T-Cell, gamma-delta
Identifiers
PMID41888575
PMCPMC13183921
What OpenQuestion holds
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LicenceCC BY
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