Evidence map›Paper›PMID 41888572›Full record

ArticleScientific reports2026

Impact of body mass index on aortic valve stenosis and its clinical outcomes in early adulthood: a long-term study of young men.

Martin Lindgren, Silvana Kontogeorgos, Amir Djekic, Martin Adiels, Susanne J Nielsen, Josefina Robertson, Zacharias Mandalenakis, Maria Åberg, N David Åberg, Demir Djekic

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Martin Lindgren *Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Silvana Kontogeorgos *Department of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Amir DjekicDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Martin AdielsDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Susanne J NielsenDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Josefina RobertsonSchool of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Zacharias MandalenakisDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Maria ÅbergSchool of Public Health and Community Medicine/Primary Health Care, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
N David ÅbergDepartment of Internal Medicine, Institute of Medicine, The Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Demir DjekicDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden. demir.djekic@gu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We investigated associations between body mass index (BMI) in adolescence with development of aortic valve stenosis (AVS) in early adulthood, and clinical outcomes among those who develop AVS. We used data from 1 701 390 men (mean age, 18.3 ± 0.8 years) enrolled in compulsory conscription for military service in Sweden from 1969 to 2005. Anthropometrics, blood pressure, fitness, muscle strength and IQ were recorded at baseline. Over a median follow-up of 32 years (IQR, 24–41 years), 5766 men were diagnosed with AVS (mean age 54.7 ± 9.4 years). After multivariable adjustment, individuals with a BMI of < 18.5 kg/m2, compared to those with a low-normal BMI (20.0–<22.5 kg/m2) showed lower risk (HR 0.70; 95% CI 0.61–0.80) of AVS. Higher BMI categories were progressively associated with increased risk, reaching HR 1.91 (95% CI 1.12–3.25) for BMI 35–50 kg/m². Further on, those diagnosed with AVS were followed for a median of ~ 5.5 years. The multivariable-adjusted HR for all-cause mortality, cardiovascular mortality, and heart failure for obese (BMI 30–50 kg/m2), compared to BMI < 20.0 kg/m2 in men diagnosed with AVS, were 4.69 (95% CI 2.61–8.44), 4.09 (95% CI 1.72–9.73), and 2.76 (95% CI, 1.36–5.60), respectively. Higher BMI in youth, even within the conventional normal range, is associated with an elevated risk of developing AVS in early adulthood, whereas low BMI appears protective. Long-term exposure of obesity in individuals with AVS is associated with worse survival and higher risk of cardiovascular events.

Indexed as

Aortic Valve StenosisBody Mass IndexObesityAdolescentAdultFollow-Up StudiesHumansMaleMiddle AgedRisk FactorsSwedenYoung AdultAortic valve stenosisBody mass indexHeart failureMortalityObesity

Identifiers

PMID41888572
PMCPMC13031306

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.