Evidence map›Paper›PMID 41888545›Full record

ArticleScientific reports2026

Oral immunization with filovirus-like particles partially protects IFNAR

Beatriz Escudero-Pérez, Fátima Lasala, Joanna Luczkowiak, Nuria Labiod, Gonzalo Rivas, Hugo Morgado, José M Casasnovas, Julia Nave, Stephanie Wurr, Juan García-Bernalt Diego and 2 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Beatriz Escudero-Pérez *Bernhard Nocht Institute for Tropical Medicine BNITM, Hamburg, Germany.
Fátima Lasala *Instituto de Investigación Hospital Universitario 12 de Octubre (Imas12), 28041, Madrid, Spain.
Joanna LuczkowiakInstituto de Investigación Hospital Universitario 12 de Octubre (Imas12), 28041, Madrid, Spain.
Nuria LabiodInstituto de Investigación Hospital Universitario 12 de Octubre (Imas12), 28041, Madrid, Spain.
Gonzalo RivasInstituto de Investigación Hospital Universitario 12 de Octubre (Imas12), 28041, Madrid, Spain.
Hugo MorgadoInstituto de Investigación Hospital Universitario 12 de Octubre (Imas12), 28041, Madrid, Spain.
José M CasasnovasCentro Nacional de Biotecnología (CNB), Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
Julia NaveBernhard Nocht Institute for Tropical Medicine BNITM, Hamburg, Germany.
Stephanie WurrBernhard Nocht Institute for Tropical Medicine BNITM, Hamburg, Germany.
Juan García-Bernalt DiegoInstituto de Investigación Hospital Universitario 12 de Octubre (Imas12), 28041, Madrid, Spain.
César Muñoz-FontelaBernhard Nocht Institute for Tropical Medicine BNITM, Hamburg, Germany.
Rafael DelgadoInstituto de Investigación Hospital Universitario 12 de Octubre (Imas12), 28041, Madrid, Spain. rafael.delgado@salud.madrid.org.

Funding

Comunidad de Madrid S2022/BMD-7274Deutsches Zentrum für Infektionsforschung TTU 01.702European and Developing Countries Clinical Trials Partnership Ebola-Prep-TBox ID 101145709Instituto de Salud Carlos III CD23/00174Instituto de Salud Carlos III CIBERINFECInstituto de Salud Carlos III CM20/00205
6 · The paper itself

Abstract

Ebola virus (EBOV), a member of the Filoviridae family, is responsible for severe hemorrhagic fever outbreaks with high case fatality rates in humans. Although injectable vaccines have shown efficacy, their deployment remains challenging in outbreak settings due to cold-chain requirements and the need for trained personnel. Oral vaccination offers an attractive alternative, combining ease of administration with the potential to induce both mucosal and systemic immunity. In this study, we evaluated the immunogenicity and protective efficacy of an orally-administered Ebola virus filovirus-like particle (EBOV-VLP) vaccine in type I interferon receptor-deficient (IFNAR

Indexed as

Ebola VaccinesEbolavirusHemorrhagic Fever, EbolaReceptor, Interferon alpha-betaVaccines, Virus-Like ParticleAdministration, OralAnimalsAntibodies, ViralFemaleImmunizationMiceMice, KnockoutVaccinationAntibodies, ViralEbola VaccinesIfnar1 protein, mouseReceptor, Interferon alpha-betaVaccines, Virus-Like Particle

Identifiers

PMID41888545
PMCPMC13172433

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.