Evidence map›Paper›PMID 41888510›Full record

ArticleNature communications2026

Genetic nurture in intergenerational transmission of substance use.

Mannan Luo, Victória Trindade Pons, Nathan A Gillespie, Hanna M van Loo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Indirect Genetic Effects on Alcohol Use Disorder and Nicotine Dependence.medRxiv : the preprint server for health sciences · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Mannan LuoDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. m.luo@umcg.nl.ORCID http://orcid.org/0000-0003-3923-2362
Victória Trindade PonsDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0001-5779-8285
Nathan A GillespieVirginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, USA.ORCID http://orcid.org/0000-0001-8655-2823
Hanna M van LooDepartment of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.ORCID http://orcid.org/0000-0002-9282-8053

Funding

Using transmitted and untransmitted gene networks to identify molecular pathways to substance use & misuse in genetically controlled twinsR01DA052453 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI GILLESPIE, NATHAN ALEXANDER, VLADIMIROV, VLADIMIR IVANOV · 2021 to 2024
$2.2M
Genetic & environmental pathways to drug use, abuse & dependenceR00DA023549 · NIDA · VIRGINIA COMMONWEALTH UNIVERSITY · PI GILLESPIE, NATHAN ALEXANDER · 2010 to 2012
$717k
U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R00DA023549U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (NIDA) R01DA052453ZonMw (Netherlands Organisation for Health Research and Development) NWO-ZonMW 09150161810021
6 · The paper itself

Abstract

Substance use runs in families. Beyond genetic transmission, parental genetics can indirectly influence offspring substance use through the rearing environment, known as genetic nurture. This study utilizes transmitted and non-transmitted polygenic scores to investigate genetic nurture on tobacco, alcohol, and cannabis use in up to 15,863 adults with at least one genotyped parent from Lifelines, a population-based cohort study. Genetic nurture significantly influences cigarettes per day (CPD, β = 0.037, p

Indexed as

Substance-Related DisordersFemaleGene-Environment InteractionGenetic Risk ScoreHumansLongitudinal StudiesMaleMultifactorial InheritanceParentsSmoking

Identifiers

PMID41888510
PMCPMC13183951

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.