Evidence map›Paper›PMID 41888493›Full record

ArticleInternational journal of bipolar disorders2026

Sleep fluctuations precede self-reported mood changes in bipolar disorder: results from the BipoSense study.

Andrea Ulrichsen, Esther Mühlbauer, Vera Miriam Ludwig, Emanuel Severus, Anthony Cleare, Sameer Jauhar, Michael Bauer, Ulrich W Ebner-Priemer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of bipolar disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea UlrichsenDepartment of Psychiatry and Psychotherapy, Dresden University of Technology, University Hospital, Dresden, Germany. andrea.ulrichsen@kcl.ac.uk.
Esther MühlbauerDepartment of Psychiatry and Psychotherapy, Dresden University of Technology, University Hospital, Dresden, Germany.
Vera Miriam LudwigDepartment of Psychiatry and Psychotherapy, Dresden University of Technology, University Hospital, Dresden, Germany.
Emanuel SeverusDepartment of Psychiatry and Psychotherapy, Dresden University of Technology, University Hospital, Dresden, Germany.
Anthony CleareInstitute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, UK.
Sameer JauharInstitute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, UK.
Michael BauerDepartment of Psychiatry and Psychotherapy, Dresden University of Technology, University Hospital, Dresden, Germany.
Ulrich W Ebner-PriemerMental mHealth Lab, Institute of Sports and Sport Sciences, Karlsruhe Institute of Technology, Karlsruhe, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe temporal relationship between sleep and mood changes in bipolar disorder (BD) has been investigated before, and this paper aims to replicate results from previous analyses while adding new details to the understanding of the relationship between fluctuations of sleep and mood. Furthermore, we comment on the use of sleep changes as a prodrome to mood changes in BD, which could improve clinical outcomes.

methodsBD outpatients in remission (N = 29) recorded daily their sleep of the past 24 h and rated their mood on a visual analogue scale for 1 year (total of 9,433 days). Cross-correlation functioning was employed to identify potential relationships between self-reported sleep values and mood scores, for both the days before and after a change in mood.

results41% of participants reported a negative relationship between changes in total time spent in bed and mood the following day, e.g. spending more time in bed before a shift towards depressive symptoms. Additionally, 21%-28% of all participants experienced an increase (or decrease) in their 7-day sleep average (sleep duration and awake in bed duration) in the week before a change in mood towards a lower (or higher) score. Only a few participants showed any relationship between changes in the 7-day variability of sleep and mood change.

conclusionOur findings align with and support those of earlier studies with similar designs. The duration of sleep and time in bed may serve as early indicators of mood changes in BD for about two-fifths of patients, and integrating these symptoms into clinical practice may help anticipate critical clinical shifts.

Indexed as

Bipolar disorderEarly warning signsLongitudinal study designSleep and mood changeSleep and mood diarySymptom prodromes

Identifiers

PMID41888493
PMCPMC13066072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.