Evidence map›Paper›PMID 41888413›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2026

Repurposing gabapentin and pregabalin to improve the anticancer efficacy of 5-fluorouracil through development of a dual-drug-loaded nanoformulation.

Chandan Raybarman, Surajit Bhattacharjee, Pratap Chandra Acharya

Abstract read
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In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Chandan RaybarmanDepartment of Molecular Biology & Bioinformatics, Tripura University (A Central University), Suryamaninagar, Tripura, 799022, India.
Surajit BhattacharjeeDepartment of Molecular Biology & Bioinformatics, Tripura University (A Central University), Suryamaninagar, Tripura, 799022, India. surajit77@tripurauniv.ac.in.
Pratap Chandra AcharyaDrug Metabolomics Laboratory, Department of Pharmacy, Tripura University (A Central University), Suryamaninagar, Tripura, 799022, India. pratapacharya@tripurauniv.ac.in.

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR24783/NER/95/851/2017
6 · The paper itself

Abstract

The antiepileptic drugs gabapentin (GBP) and pregabalin (PGB) act by modulating α2δ-1 calcium channel subunits, which are overexpressed in tumor-initiating cells. Therefore, this study investigates repurposing GBP and PGB in enhancing anticancer efficiency of 5-fluorouracil (5-FU) through a dual-drug-loaded ethyl cellulose nanoparticles (ECNPs) formulation. The ECNPs are prepared using a modified nanoprecipitation method and characterized for particle size, encapsulation and loading efficiencies, and in vitro anticancer efficacy. They exhibited pronounced anticancer efficacy against COLO-205 human colon cancer cell line, with GI

Indexed as

Antimetabolites, AntineoplasticAntineoplastic AgentsCyclohexanecarboxylic AcidsFluorouracilGabapentinNanoparticlesPregabalinCell Line, TumorCell SurvivalDrug Repositioninggamma-Aminobutyric AcidHumansParticle SizeAntimetabolites, AntineoplasticAntineoplastic AgentsCyclohexanecarboxylic AcidsFluorouracilGabapentingamma-Aminobutyric AcidPregabalin5-FluorouracilCancer cell linesEthylcelluloseGabapentinNanoparticlesPregabalin

Identifiers

PMID41888413

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.