Evidence map›Paper›PMID 41888329›Full record

SynthesisCognitive, affective & behavioral neuroscience2026

Neuropsychiatric symptoms and their impact on cognitive functioning in patients with parkinson's disease: A systematic review of the literature.

Barbara Blasutto, Giulia Matrone, Byron Creese, Francesco Fattapposta, Maria Casagrande

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Cognitive, affective & behavioral neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Barbara BlasuttoDepartment of Psychology- "Sapienza", University of Rome, Via dei Marsi 78, 00185, Rome, Italy. barbara.blasutto@uniroma1.it.ORCID http://orcid.org/0009-0001-6316-7145
Giulia MatroneDepartment of Dynamic and Clinical Psychology, and Health Studies - "Sapienza", University of Rome, Via degli Apuli 1, 00185, Rome, Italy.
Byron CreeseDepartment of Psychology, College Health Medicine and Life Sciences, Brunel University of London, London, UK.
Francesco FattappostaDepartment of Human Neuroscience, "Sapienza" University of Rome, Viale dell'Università 30, 00185, Rome, Italy.
Maria CasagrandeDepartment of Dynamic and Clinical Psychology, and Health Studies - "Sapienza", University of Rome, Via degli Apuli 1, 00185, Rome, Italy. maria.casagrande@uniroma1.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive, neurodegenerative disorder that affects the dopaminergic system and is characterized by motor and nonmotor symptoms, which affect the quality of life. Among these, neuropsychiatric symptoms (NPS), such as depression, hallucinations, and apathy, are common and can accelerate cognitive decline. Although the association between some specific NPS (e.g., apathy) and cognitive functions has been investigated, no review has systematically examined the relationship between the whole of NPS and cognitive functions in PD patients without dementia. Therefore, the purpose of this study was to analyze the relationship between NPS taken together and cognitive impairment in patients with PD. According to the PRISMA-Statement, this systematic review critically examined the difference in cognitive performance between patients diagnosed with idiopathic PD with and without NPS. Results were classified according to the cognitive domain evaluated. Eleven studies met the eligibility criteria. The results showed that PD patients with NPS showed impaired performance on cognitive tasks compared with those without NPS, as well as in longitudinal studies. These results were also confirmed when the different domains were considered separately. Despite the limited number of included studies, the importance of assessing NPS in their totality rather than individual behavioral symptoms emerges. Clinical manifestations may vary among individuals and across different stages of the disease. Therefore, assessing the presence of these symptoms and the timing of their onset would be appropriate and may give the clinician important insights into the possible course and management of the disease.

Indexed as

ApathyCognitionCognitive DysfunctionDepressionParkinson DiseaseBehavioral SymptomsHumansNeuropsychological TestsCognitive declineMild behavioral impairmentNeuropsychiatric symptomsParkinson's diseaseSystematic review

Identifiers

PMID41888329
PMCPMC13615131

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.