Evidence map›Paper›PMID 41888313›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Clinical and immunological features of auto-immune nodopathies.

Meng Dong, Xiaozhen Gao, ChaoYi Yu, Zaiqiang Zhang

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Meng DongDepartment of Neurology, Beijing Shunyi Hospital, Beijing Shunyi Teaching Hospital of Capital Medical University, Beijing, China.
Xiaozhen GaoDepartment of Neurology, Beijing ShunYi KongGang Hostital, Beijing, China.
ChaoYi YuDepartment of Neurology, Beijing ShunYi KongGang Hostital, Beijing, China.
Zaiqiang ZhangDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Fengtai District, Beijing, 100070, China. ttyy0142011@126.com.ORCID http://orcid.org/0000-0002-0053-3451

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe aimed to evaluate the detection rates of antibodies against nodal-paranodal junction proteins in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), and to analyze the clinical, laboratory, and neuroelectrophysiological characteristics of antibody-positive patients.

methodsA total of 45 patients with CIDP were enrolled. Serum samples were collected, and cell-based assay (CBA) was used to detect IgG against human neurofascin-155 (NF155), neurofascin-186 (NF186), contactin-1 (CNTN1), contactin-2 (CNTN2) and contactin-associated protein 1 (CASPR1).

resultsSix patients (13.3%) had IgG against NF155, 2 (4.4%) against CASPR1, 2 (4.4%) against NF186 and 1 (2.2%) against CNTN1. Seropositive patients had elevated cerebrospinal fluid (CSF) protein, higher CSF cells than seronegative patients. Patients seropositive for NF155-IgG exhibited an earlier disease onset and demonstrated higher prevalence of limb tremors and sensory ataxia compared to their seronegative counterparts. Among 11 seropositive patients, intravenous immunoglobins (IVIG) achieved good response in 1/7 (14.3%) cases. Rituximab showed good response in 6/8 (75.0%) cases.

conclusionsAuto-immune nodopathies represent a distinct clinical entity from CIDP.

Indexed as

AutoantibodiesPolyradiculoneuropathy, Chronic Inflammatory DemyelinatingAdultAgedCell Adhesion MoleculesCell Adhesion Molecules, NeuronalContactin 1Contactin 2FemaleHumansImmunoglobulin GMaleMiddle AgedNerve Growth FactorsAutoantibodiesCell Adhesion MoleculesCell Adhesion Molecules, NeuronalCNTN1 protein, humanCNTN2 protein, humanContactin 1Contactin 2Immunoglobulin GNerve Growth FactorsNFASC protein, humanAntibodyAuto-immune nodopathiesChronic inflammatory demyelinating polyneuropathyRanvier node

Identifiers

PMID41888313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.