Evidence map›Paper›PMID 41888142›Full record

ArticleNature communications2026

Structural and evolutionary insights into the eukaryotic RNase MRP ribonucleoprotein complex.

Bin Zhou, Xiaozhu Wang, Futang Wan, Shaobai Li, Xiaoshuang Zhang, Yuanyuan Zhang, Ming Tan, Mi Cao, Yafeng Shen, Rui Gao and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Bin Zhou *Department of Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaozhu Wang *Shanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-3982-1186
Futang Wan *Cancer Institute, The Affiliated Hospital of Qingdao University, Qingdao Cancer Institute, Qingdao University, Qingdao, China.
Shaobai LiShanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoshuang ZhangShanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yuanyuan ZhangShanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ming TanDepartment of Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-6315-669X
Mi CaoShanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yafeng ShenShanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Rui GaoFrontier Science Center for Stem Cell Research, Tongji University, Shanghai, China.
Yanjie ZhangDepartment of Oncology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zhangyanjie@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-7425-8632
Pengfei LanInstitute of Aging and Tissue Regeneration, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. pengfeilan@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-7654-2717
Jian WuShanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. wujian@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-2072-0967
Ming LeiShanghai Institute of Precision Medicine, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. leim@shsmu.edu.cn.ORCID http://orcid.org/0000-0002-1153-4791

Funding

National Natural Science Foundation of China (National Science Foundation of China) 31930063National Natural Science Foundation of China (National Science Foundation of China) 32400499National Natural Science Foundation of China (National Science Foundation of China) 32430033National Natural Science Foundation of China (National Science Foundation of China) 32471339National Natural Science Foundation of China (National Science Foundation of China) 82072638
6 · The paper itself

Abstract

RNase MRP is a conserved eukaryotic ribonucleoprotein essential for precursor-rRNA processing and ribosome assembly. Despite previous studies of yeast RNase MRP, the composition of RNase MRP and how it adapts to process flexible, single-stranded rRNA substrates in most eukaryotes remain enigmatic. Here, we perform an integrative structural, evolutionary, and functional dissection of human RNase MRP. Using structure-based bioinformatics and cryo-EM structural analyses, we identify NEPRO (RMP64) and C18orf21 (RMP24) as the bona fide subunits unique to RNase MRP, which are indispensable for precursor-rRNA cleavage, ribosome assembly, protein synthesis, and chondrogenesis. The structure of human RNase MRP reveals a unique 'double-anchor' substrate-binding mechanism that underlies evolutionary adaptations conferring broad substrate specificity. Our work on RNase MRP provides a unified evolutionary and mechanistic framework for this essential ancient ribozyme.

Indexed as

EndoribonucleasesEvolution, MolecularRibonucleoproteinsCryoelectron MicroscopyHumansModels, MolecularRNA, RibosomalSubstrate SpecificityEndoribonucleasesmitochondrial RNA-processing endoribonucleaseRibonucleoproteinsRNA, Ribosomal

Identifiers

PMID41888142
PMCPMC13184271

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.