ArticleNature communications2026
Proton signaling links epithelial sensing to neural control of host defense in C. elegans.
Ying Lei, Xu Zhan, Chao Chen, Yuxin Liu, Ying Wang, Ping Liu
Abstract read
In one paragraphArticle in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Ying Lei *Department of Pathophysiology, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.ORCID http://orcid.org/0000-0002-6020-6428 Xu Zhan *Department of Pathophysiology, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Yuxin LiuDepartment of Pathophysiology, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ying WangDepartment of Pathophysiology, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
Ping LiuDepartment of Pathophysiology, Key Laboratory of Ministry of Education of China and Hubei Province for Neurological Disorders, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. pingl@hust.edu.cn.ORCID http://orcid.org/0000-0003-4909-4282 Funding
National Natural Science Foundation of China (National Science Foundation of China) 32171003National Natural Science Foundation of China (National Science Foundation of China) 32571188
6 · The paper itselfAbstract
Effective host defense against pathogens requires coordinated behavioral and immune responses, yet the mechanisms that couple epithelial sensing to these systemic defenses remain poorly understood. Here, we identify a proton-mediated gut-to-neuron signaling pathway that orchestrates host defense in C. elegans. Intestinal pathogens stimulate mechanosensitive Ca
Indexed as
Caenorhabditis elegansProtonsAcid Sensing Ion ChannelsAnimalsCaenorhabditis elegans ProteinsCalciumCalmodulinCholinergic NeuronsEpithelial CellsImmunity, InnateIntestinal MucosaMiceSignal TransductionSodium-Hydrogen ExchangersAcid Sensing Ion ChannelsASIC1 protein, mouseCaenorhabditis elegans ProteinsCalciumCalmodulinProtonsSodium-Hydrogen Exchangers
Identifiers
PMID41888139
PMCPMC13187020
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