Evidence map›Paper›PMID 41888118›Full record

ArticleCell death & disease2026

Tumor suppressor function of SHMT in a Drosophila Ras

Chiara Angioli, Angelo Ferriero, Eleonora Pilesi, Giulia Tesoriere, Beatrice Agostini, Angela Tramonti, Roberto Contestabile, Fiammetta Vernì

Erratum issuedAbstract read
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In one paragraph

Article in Cell death & disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. From Fly to Human: Translational Relevance ofInternational journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Chiara Angioli *Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-7958-2327
Angelo Ferriero *Dept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0009-0000-1087-3436
Eleonora PilesiDept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Giulia TesoriereDept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Rome, Italy.
Beatrice AgostiniDept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Rome, Italy.ORCID http://orcid.org/0009-0009-1891-9473
Angela TramontiInstitute of Molecular Biology and Pathology, National Research Council, Rome, Italy.ORCID http://orcid.org/0000-0002-5625-1170
Roberto ContestabileDepartment of Biochemical Sciences "A. Rossi Fanelli", Sapienza, University of Rome, Rome, Italy.ORCID http://orcid.org/0000-0002-5235-9993
Fiammetta VernìDept. of Biology and Biotechnology "Charles Darwin", Sapienza University of Rome, Rome, Italy. Fiammetta.verni@uniroma1.it.ORCID http://orcid.org/0000-0001-8866-3324

Funding

Sapienza Università di Roma (Sapienza University of Rome) AR1231889041EBDDSapienza Università di Roma (Sapienza University of Rome) AR1241905DD95C63
6 · The paper itself

Abstract

Serine hydroxymethyltransferase (SHMT) is a key enzyme in one-carbon (1 C) metabolism, essential for nucleotide synthesis and epigenetic maintenance. In mammals, there are two distinct SHMT isozymes: the cytosolic SHMT1 and the mitochondrial SHMT2. Several studies report that high SHMT levels in cancer contribute to metabolic reprogramming. Conversely, a limited number of studies have linked decreased SHMT1 expression to the progression and poor prognosis of hepatocellular carcinoma and renal cell carcinoma, suggesting that SHMT may play dual roles as an oncogene or tumor suppressor, depending on the cellular context. However, the molecular mechanisms underlying SHMT tumor suppressor role remain unknown. In this work, we used the Drosophila Ras

Indexed as

DNA DamageDrosophila melanogasterDrosophila ProteinsGlycine HydroxymethyltransferasePyridoxal PhosphateAnimalsGenomic InstabilityMetabolic ReprogrammingOxidative StressReactive Oxygen SpeciesDrosophila ProteinsGlycine HydroxymethyltransferasePyridoxal PhosphateReactive Oxygen Species

Identifiers

PMID41888118
PMCPMC13153359

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.