ArticleJournal of clinical periodontology2026
Salivary Microvesicle Methylome and Microbiome Profiles in Periodontitis: An Exploratory Study.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
aimSalivary microvesicles (MVs) are nanosized extracellular vesicles from the host and microbiota whose cargo may mirror the biological state of their parent cells. This cross-sectional study aimed to explore the diagnostic power of host methylome and microbiome profiles of MVs in various periodontal disease states. MATERIALS AND
methodsThis exploratory study recruited 20 healthy, 16 gingivitis and 26 stage III/IV periodontitis cases. The origins of salivary host-MVs were identified using a multiplex extracellular vesicle (EV) kit. The microbiome and host methylome profiles of MV DNA were analysed using 16S rRNA sequencing and methylated DNA immunoprecipitation sequencing (MeDIP-seq), respectively.
resultsThe periodontitis group showed increased CD63+, CD45+, CD29
conclusionThis exploratory study found that host methylome and microbiome profiles in salivary MVs reflect periodontal disease status, and hence supports their potential as non-invasive liquid biopsy biomarkers for periodontitis.
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