ArticleOrganic letters2026
Lewis Acid Catalyzed Dual Strain-Release Platform for Transforming Azabicyclo[1.1.0]butanes into Functionalized Azetidines with Donor-Acceptor(D-A) Cyclopropanes and Bicyclo[1.1.0]butanes.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Herein, we disclose a catalytic dual strain-release approach that achieves orthogonal N1 and C3 functionalization of azabicyclo[1.1.0]butanes (ABBs) through synergistic engagement with donor-acceptor cyclopropanes (DACs). Orthogonal Lewis acid polarization of the cyclopropane relays activation to ABB, permitting access to functionalized azetidines, through cleavage of the strained C-N bond of ABB. Extending this activation paradigm to bicyclo[1.1.0]butanes (BCBs) further demonstrates the generality of this concept.
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