ArticleNan fang yi ke da xue xue bao = Journal of Southern Medical University2026
[Folic acid supplementation alleviates high-salt diet-induced renal fibrosis in mice].
Article in Nan fang yi ke da xue xue bao = Journal of Southern Medical University, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo investigate the protective effect of 2-week dietary folic acid (FA) supplementation against renal fibrosis induced by high-salt (HS) diet in mice.
methodsTwenty-eight mice were randomly divided into control, HS (8% NaCl) diet group, HS+low-dose FA (FA: 0.56 mg/kg) group and HS+high-dose FA (5.6 mg/kg) group. The changes in body weight, food intake, water consumption, tail artery systolic pressure, and heart rate of the mice were monitored, and serum levels of creatinine (SCr) and inflammatory cytokines (IL-1β, IL-6, and TNF-α) were measured. Renal histopathology of the mice was assessed using HE, periodic acid-Schiff (PAS), Masson, and Sirius red staining. Renal expressions of
resultsIn mice feeding a HS diet, FA supplementation significantly reduced their water intake, lowered tail artery systolic pressure, heart rate, renal index and serum SCr levels, reducing also serum levels of TNF‑α , IL-1β, and IL-6. Masson and Sirius red staining revealed markedly reduced glomerular and interstitial fibrosis indices in HS+low-dose FA group, while the mice in HS+high-dose FA group showed mixed fibrotic improvements. Immunohistochemical results demonstrated that FA significantly upregulated E-cadherin protein expression and suppressed vimentin expression in renal tissues. Both FA doses inhibited HS-induced mRNA and protein expressions of fibrosis markers (
conclusionsFA intervention ameliorates renal inflammation and delays fibrosis progression in HS-fed mice. Low-dose FA supplementation produces better protective effect than high-dose FA, likely mediated by regulation of renal
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